PDB
8K2W
Resolution
3.0 Å
Released
Nov. 29, 2023
Receptor
CXCR3
Class
A
Species
Homo sapiens
Ligand
CHEMBL397983
Function
Antagonist
Reference
10.1038/S41421-023-00617-0

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL397983 Y60 1.39x39 TM1 hydrophobic
CHEMBL397983 W109 2.60x60 TM2 aromatic (face-to-face)
CHEMBL397983 S309 7.36x35 TM7 Van der Waals
CHEMBL397983 S309 7.36x35 TM7 polar (hydrogen bond)
CHEMBL397983 S312 7.39x38 TM7 polar (hydrogen bond)
CHEMBL397983 S312 7.39x38 TM7 Van der Waals
CHEMBL397983 Y316 7.43x42 TM7 aromatic (face-to-face)
CHEMBL397983 Y316 7.43x42 TM7 polar (hydrogen bond)
CHEMBL397983 Y316 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
Helix box plot — Download: PNG | SVG G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7

GPCRdb(A)
GPCRdb(A)
CXCR3
TM1
1x39 1.39x39 Y60
TM2
2x60 2.60x60 W109
TM7
7x35 7.36x35 S301
7x38 7.39x38 S304
7x42 7.43x42 Y308