Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8K8J

SPECIES

Homo sapiens

RESOLUTION

2.880

PREFERRED CHAIN

R

REFERENCE

10.1002/ADVS.202306311

PUBLICATION DATE

Feb. 14, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
FENOFIBRATE F170 2.57x57 TM2 hydrophobic
FENOFIBRATE S173 2.60x60 TM2 Van der Waals
FENOFIBRATE S173 2.60x60 TM2 polar (hydrogen bond)
FENOFIBRATE F174 2.61x61 TM2 aromatic (edge-to-face)
FENOFIBRATE F174 2.61x61 TM2 Van der Waals
FENOFIBRATE F177 2.64x64 TM2 aromatic (face-to-edge)
FENOFIBRATE F177 2.64x64 TM2 Van der Waals
FENOFIBRATE H178 2.65x65 TM2 Van der Waals
FENOFIBRATE L193 3.29x29 TM3 hydrophobic
FENOFIBRATE L193 3.29x29 TM3 Van der Waals
FENOFIBRATE V196 3.32x32 TM3 hydrophobic
FENOFIBRATE V196 3.32x32 TM3 Van der Waals
FENOFIBRATE T197 3.33x33 TM3 Van der Waals
FENOFIBRATE F200 3.36x36 TM3 hydrophobic
FENOFIBRATE F200 3.36x36 TM3 Van der Waals
FENOFIBRATE F268 ECL2 hydrophobic
FENOFIBRATE F268 ECL2 Van der Waals
FENOFIBRATE W279 5.43x43 TM5 hydrophobic
FENOFIBRATE W279 5.43x43 TM5 Van der Waals
FENOFIBRATE M363 6.55x55 TM6 hydrophobic
FENOFIBRATE M363 6.55x55 TM6 Van der Waals

Ligands

FENOFIBRATE

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x60 2.60x60 S173
2x61 2.61x61 F174
2x64 2.64x64 F177
2x65 2.65x65 H178
TM3
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM5
5x43 5.43x43 W279
TM6
6x55 6.55x55 M363