PDB
8K9L
Resolution
3.1 Å
Released
May 29, 2024
Receptor
μ
Class
A
Species
Homo sapiens
Ligands
DAMGO
BMS-986122
Function
Agonist
PAM
Reference
10.1038/S41467-024-47792-6
DAMGO BMS-986122

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Ligand Amino Acid Generic Number Segment Interaction Type
DAMGO V145 3.28x28 TM3 hydrophobic
DAMGO I146 3.29x29 TM3 hydrophobic
DAMGO M153 3.36x36 TM3 hydrophobic
BMS-986122 W158 3.41x41 TM3 aromatic (face-to-face)
BMS-986122 T162 3.45x45 TM3 polar (hydrogen bond)
BMS-986122 T162 3.45x45 TM3 polar (hydrogen bond with backbone)
BMS-986122 V165 3.48x48 TM3 Van der Waals
BMS-986122 V165 3.48x48 TM3 hydrophobic
BMS-986122 D166 3.49x49 TM3 Van der Waals
BMS-986122 F180 34.56x56 ICL2 Van der Waals
BMS-986122 F180 34.56x56 ICL2 hydrophobic
BMS-986122 I189 4.45x45 TM4 Van der Waals
BMS-986122 N193 4.49x49 TM4 Van der Waals
DAMGO V238 5.42x43 TM5 hydrophobic
BMS-986122 F241 5.45x46 TM5 hydrophobic
BMS-986122 F241 5.45x46 TM5 Van der Waals
BMS-986122 M245 5.49x49 TM5 polar (hydrogen bond)
BMS-986122 P246 5.50x50 TM5 Van der Waals
DAMGO W320 7.35x34 TM7 hydrophobic
DAMGO I324 7.39x38 TM7 hydrophobic
DAMGO Y328 7.43x42 TM7 polar (hydrogen bond)
DAMGO Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x36 3.36x36 M153
3x41 3.41x41 F158
3x45 3.45x45 T162
3x48 3.48x48 V165
3x49 3.49x49 D166
ICL2
34x56 34.56x56 F180
TM4
4x45 4.45x45 I189
4x49 4.49x49 N193
TM5
5x43 5.42x43 V238
5x46 5.45x46 F241
5x49 5.49x49 M245
5x50 5.50x50 P246
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328