PDB
8KFY
Resolution
3.1 Å
Released
Feb. 7, 2024
Receptor
CCR8
Class
A
Species
Homo sapiens
Ligand
ZK 756326
Function
Agonist
Reference
10.1126/SCIADV.ADJ7500

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Ligand Amino Acid Generic Number Segment Interaction Type
ZK 756326 Y42 1.39x39 TM1 hydrophobic
ZK 756326 W99 23.50x50 ECL1 hydrophobic
ZK 756326 Y113 3.32x32 TM3 hydrophobic
ZK 756326 Y114 3.33x33 TM3 polar (hydrogen bond)
ZK 756326 Y172 ECL2 Van der Waals
ZK 756326 Y172 ECL2 hydrophobic
ZK 756326 C183 45.50x50 ECL2 Van der Waals
ZK 756326 T198 5.38x39 TM5 polar (hydrogen bond)
ZK 756326 L258 6.55x55 TM6 Van der Waals
ZK 756326 E286 7.39x38 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Q W V F ECL1ICL2 A V Y A L K V R ICL2ECL2 Q V A S E D G V L Q C Y S F Y N Q Q ECL2ICL3 Q N ICL3ECL3 L D ECL3N-term M D Y T L D L S V T T V T D Y Y Y P D I F S S P C D A E L I N-termC-term S C S Q I F N Y L G R Q M P R E S C E K S S S C Q Q H S S R S S S V D Y I L C-term Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H T I R M G T T L C L A V W L T A I M A T I P L L V F Y T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K L S E F K K H I F Q K
Helix box plot — Download: PNG | SVG S N G L L S F V F L L C Y F V A L L L K 1 L N L A L S D L L F V F S F P F Q T Y Y 2 L T I F F M S S Y F G I Y Y F G S V V K 3 G T T L C L A V W L T A I M A T I P L 4 Y C F M F I T F P I L L G L I N M K F N T 5 L I V V I A S L L F W V P F N V V L F L 6 V P N V C C H T F S I I E T V H T A Y 7

GPCRdb(A)
GPCRdb(A)
CCR8
TM1
1x39 1.39x39 Y42
ECL1
23x50 23.50x50 W99
TM3
3x32 3.32x32 Y113
3x33 3.33x33 Y114
ECL2
45x50 45.50x50 C183
TM5
5x39 5.38x39 T198
TM6
6x55 6.55x55 L258
TM7
7x38 7.39x38 E286