PDB
8TAO
Resolution
2.9 Å
Released
Oct. 11, 2023
Receptor
mGlu5
Class
C
Species
Homo sapiens
Ligands
Function
CDPPB
Ago-PAM
Nanobody 43
PAM
quisqualate
Agonist
Reference
10.1101/2023.08.29.555158
CDPPB Nanobody 43 quisqualate

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Ligand Amino Acid Generic Number Segment Interaction Type
Nanobody 43 R25 N-term hydrophobic
Nanobody 43 V27 N-term Van der Waals
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate W100 N-term aromatic (edge-to-face)
quisqualate G150 N-term Van der Waals
quisqualate S151 N-term Van der Waals
quisqualate S152 N-term polar (hydrogen bond)
quisqualate S173 N-term polar (hydrogen bond with backbone)
quisqualate A174 N-term Van der Waals
quisqualate T175 N-term Van der Waals
quisqualate Y223 N-term aromatic (pi-cation)
quisqualate E279 N-term Van der Waals
quisqualate G280 N-term Van der Waals
quisqualate D305 N-term polar (charge-charge)
quisqualate D305 N-term polar (hydrogen bond)
quisqualate G306 N-term Van der Waals
quisqualate R310 N-term polar (charge-charge)
Nanobody 43 E347 N-term Van der Waals
Nanobody 43 N349 N-term Van der Waals
Nanobody 43 H350 N-term Van der Waals
Nanobody 43 R351 N-term Van der Waals
Nanobody 43 N352 N-term Van der Waals
Nanobody 43 P353 N-term hydrophobic
Nanobody 43 Q356 N-term Van der Waals
Nanobody 43 E368 N-term Van der Waals
Nanobody 43 G369 N-term polar (hydrogen bond with backbone)
Nanobody 43 F370 N-term hydrophobic
Nanobody 43 P371 N-term polar (hydrogen bond with backbone)
Nanobody 43 P371 N-term hydrophobic
Nanobody 43 Q372 N-term polar (hydrogen bond)
Nanobody 43 E373 N-term polar (hydrogen bond)
Nanobody 43 S375 N-term Van der Waals
quisqualate K396 N-term Van der Waals
CDPPB I625 2.46x46 TM2 Van der Waals
CDPPB G628 2.49x49 TM2 Van der Waals
CDPPB S654 3.39x39 TM3 Van der Waals
CDPPB P655 3.40x40 TM3 hydrophobic
CDPPB Y659 3.44x44 TM3 hydrophobic
CDPPB L744 5.44x44 TM5 hydrophobic
CDPPB N747 5.47x47 TM5 Van der Waals
CDPPB I751 5.51x51 TM5 Van der Waals
CDPPB T781 6.46x46 TM6 hydrophobic
CDPPB C782 6.47x47 TM6 Van der Waals
CDPPB W785 6.50x50 TM6 aromatic (face-to-face)
CDPPB W785 6.50x50 TM6 hydrophobic
CDPPB M802 7.32x33 TM7 Van der Waals
CDPPB S805 7.35x36 TM7 Van der Waals
CDPPB V806 7.36x37 TM7 hydrophobic
CDPPB S809 7.39x40 TM7 Van der Waals
CDPPB A810 7.40x41 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu5 receptor
TM2
2x50 2.46x46 I625
2x53 2.49x49 G628
TM3
3x35 3.39x39 S654
3x36 3.40x40 P655
3x40 3.44x44 Y659
TM5
5x44 5.44x44 L744
5x47 5.47x47 N747
5x51 5.51x51 I751
TM6
6x44 6.46x46 T781
6x45 6.47x47 C782
6x48 6.50x50 W785
TM7
7x38 7.32x33 M802
7x41 7.35x36 S805
7x42 7.36x37 V806
7x45 7.39x40 S809
7x46 7.40x41 A810