Structure information

AT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8TH3

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-024-01620-6

PUBLICATION DATE

May 22, 2024

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AT118-H Nanobody R167 ECL2 polar (charge-assisted hydrogen bond)
AT118-H Nanobody F170 ECL2 aromatic (edge-to-face)
AT118-H Nanobody F170 ECL2 Van der Waals
AT118-H Nanobody I172 ECL2 Van der Waals
AT118-H Nanobody I172 ECL2 hydrophobic
AT118-H Nanobody E173 ECL2 polar (charge-assisted hydrogen bond)
AT118-H Nanobody N174 ECL2 Van der Waals
AT118-H Nanobody N174 ECL2 polar (hydrogen bond)
AT118-H Nanobody V179 ECL2 hydrophobic
AT118-H Nanobody V179 ECL2 Van der Waals
AT118-H Nanobody C180 45.50x50 ECL2 Van der Waals
AT118-H Nanobody A181 45.51x51 ECL2 Van der Waals
AT118-H Nanobody A181 45.51x51 ECL2 hydrophobic
AT118-H Nanobody F182 45.52x52 ECL2 Van der Waals
AT118-H Nanobody F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
AT118-H Nanobody H183 ECL2 polar (hydrogen bond)
AT118-H Nanobody Y184 ECL2 polar (hydrogen bond)
AT118-H Nanobody Y184 ECL2 polar (hydrogen bond with backbone)
AT118-H Nanobody E185 ECL2 Van der Waals
AT118-H Nanobody S186 ECL2 polar (hydrogen bond with backbone)
AT118-H Nanobody S186 ECL2 Van der Waals
AT118-H Nanobody Q187 ECL2 polar (hydrogen bond)
AT118-H Nanobody P192 5.35x36 TM5 hydrophobic
AT118-H Nanobody P192 5.35x36 TM5 Van der Waals
AT118-H Nanobody I1266 6.61x61 TM6 hydrophobic
AT118-H Nanobody I1266 6.61x61 TM6 Van der Waals
AT118-H Nanobody Q1267 6.62x62 TM6 polar (hydrogen bond)
AT118-H Nanobody Q1267 6.62x62 TM6 polar (hydrogen bond)
AT118-H Nanobody R1272 ECL3 Van der Waals
AT118-H Nanobody A1277 7.28x27 TM7 Van der Waals
AT118-H Nanobody D1278 7.29x28 TM7 polar (charge-assisted hydrogen bond)
AT118-H Nanobody D1281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
AT118-H Nanobody D1281 7.32x31 TM7 polar (hydrogen bond with backbone)
AT118-H Nanobody M1284 7.35x34 TM7 Van der Waals

Ligands

AT118-H Nanobody

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7
Download: PNG | SVG
ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
AT1 receptor
ECL2
45x50 45.50x50 C180
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x36 5.35x36 P192
TM6
6x61 6.61x61 I266
6x62 6.62x62 Q267
TM7
7x27 7.28x27 A277
7x28 7.29x28 D278
7x31 7.32x31 D281
7x34 7.35x34 M284