Structure information

AT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8TH4

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-024-01620-6

PUBLICATION DATE

May 22, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AT118-L Nanobody Y92 ECL1 polar (hydrogen bond)
AT118-L Nanobody F170 ECL2 hydrophobic
AT118-L Nanobody F170 ECL2 Van der Waals
AT118-L Nanobody I172 ECL2 Van der Waals
AT118-L Nanobody I172 ECL2 hydrophobic
AT118-L Nanobody E173 ECL2 polar (charge-assisted hydrogen bond)
AT118-L Nanobody N174 ECL2 polar (hydrogen bond)
AT118-L Nanobody A181 45.51x51 ECL2 hydrophobic
AT118-L Nanobody A181 45.51x51 ECL2 Van der Waals
AT118-L Nanobody F182 45.52x52 ECL2 Van der Waals
AT118-L Nanobody F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
AT118-L Nanobody H183 ECL2 polar (hydrogen bond)
AT118-L Nanobody Y184 ECL2 Van der Waals
AT118-L Nanobody Y184 ECL2 polar (hydrogen bond with backbone)
AT118-L Nanobody E185 ECL2 Van der Waals
AT118-L Nanobody S186 ECL2 Van der Waals
AT118-L Nanobody Q187 ECL2 polar (hydrogen bond)
AT118-L Nanobody Q187 ECL2 Van der Waals
AT118-L Nanobody N188 ECL2 Van der Waals
AT118-L Nanobody D1263 6.58x58 TM6 Van der Waals
AT118-L Nanobody I1266 6.61x61 TM6 Van der Waals
AT118-L Nanobody Q1267 6.62x62 TM6 Van der Waals
AT118-L Nanobody Q1267 6.62x62 TM6 polar (hydrogen bond)
AT118-L Nanobody A1277 7.28x27 TM7 Van der Waals
AT118-L Nanobody D1281 7.32x31 TM7 polar (hydrogen bond with backbone)
AT118-L Nanobody D1281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
AT118-L Nanobody M1284 7.35x34 TM7 polar (hydrogen bond)
AT118-L Nanobody P1285 7.36x35 TM7 Van der Waals
AT118-L Nanobody P1285 7.36x35 TM7 hydrophobic

Ligands

AT118-L Nanobody

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Residue Diagrams

S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7
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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT1 receptor
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM6
6x58 6.58x58 D263
6x61 6.61x61 I266
6x62 6.62x62 Q267
TM7
7x27 7.28x27 A277
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285