PDB
8TLM
Resolution
2.9 Å
Released
Dec. 20, 2023
Receptor
CCR8
Class
A
Species
Homo sapiens
Ligands
mAb1 Fab fragment (chain A)
mAb1 Fab fragment (chain B)
Function
Antagonist
Antagonist
Reference
10.1038/S41467-023-43601-8
mAb1 Fab fragment (chain A) mAb1 Fab fragment (chain B)

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Ligand Amino Acid Generic Number Segment Interaction Type
mAb1 Fab fragment (chain A) Q98 23.49x49 ECL1 polar (hydrogen bond)
mAb1 Fab fragment (chain A) T103 3.22x22 TM3 polar (hydrogen bond)
mAb1 Fab fragment (chain A) T103 3.22x22 TM3 Van der Waals
mAb1 Fab fragment (chain A) Q173 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain A) Q173 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain A) V174 ECL2 Van der Waals
mAb1 Fab fragment (chain A) V174 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) A175 ECL2 Van der Waals
mAb1 Fab fragment (chain A) S176 ECL2 Van der Waals
mAb1 Fab fragment (chain A) S176 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain A) S176 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) E177 ECL2 polar (charge-assisted hydrogen bond)
mAb1 Fab fragment (chain A) D178 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) D178 ECL2 polar (charge-assisted hydrogen bond)
mAb1 Fab fragment (chain A) G179 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) G179 ECL2 Van der Waals
mAb1 Fab fragment (chain A) L181 ECL2 hydrophobic
mAb1 Fab fragment (chain A) L181 ECL2 Van der Waals
mAb1 Fab fragment (chain A) Y187 ECL2 polar (hydrogen bond with backbone)
mAb1 Fab fragment (chain A) Y187 ECL2 Van der Waals
mAb1 Fab fragment (chain B) N188 ECL2 Van der Waals
mAb1 Fab fragment (chain B) Q189 ECL2 polar (hydrogen bond)
mAb1 Fab fragment (chain B) Q189 ECL2 Van der Waals
mAb1 Fab fragment (chain B) Q190 ECL2 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Q W V F ECL1ICL2 A V Y A L K V R ICL2ECL2 Q V A S E D G V L Q C Y S F Y N Q Q ECL2ICL3 Q N ICL3ECL3 L D ECL3N-term M D Y T L D L S V T T V T D Y Y Y P D I F S S P C D A E L I N-termC-term S C S Q I F N Y L G R Q M P R E S C E K S S S C Q Q H S S R S S S V D Y I L C-term Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H T I R M G T T L C L A V W L T A I M A T I P L L V F Y T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K L S E F K K H I F Q K
Helix box plot — Download: PNG | SVG S N G L L S F V F L L C Y F V A L L L K 1 L N L A L S D L L F V F S F P F Q T Y Y 2 L T I F F M S S Y F G I Y Y F G S V V K 3 G T T L C L A V W L T A I M A T I P L 4 Y C F M F I T F P I L L G L I N M K F N T 5 L I V V I A S L L F W V P F N V V L F L 6 V P N V C C H T F S I I E T V H T A Y 7

GPCRdb(A)
GPCRdb(A)
CCR8
ECL1
23x49 23.49x49 Q98
TM3
3x22 3.22x22 T103