PDB
8UWL
Resolution
2.8 Å
Released
May 29, 2024
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
lisuride
Function
Agonist (partial)
Reference
10.1126/SCIENCE.ADN6354

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Ligand Amino Acid Generic Number Segment Interaction Type
lisuride W151 3.28x28 TM3 hydrophobic
lisuride D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
lisuride V156 3.33x33 TM3 hydrophobic
lisuride V156 3.33x33 TM3 Van der Waals
lisuride S159 3.36x36 TM3 Van der Waals
lisuride T160 3.37x37 TM3 Van der Waals
lisuride S242 5.46x461 TM5 Van der Waals
lisuride F339 6.51x51 TM6 Van der Waals
lisuride F339 6.51x51 TM6 hydrophobic
lisuride F340 6.52x52 TM6 aromatic (edge-to-face)
lisuride V366 7.39x38 TM7 hydrophobic

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
TM5
5x461 5.46x461 S242
TM6
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366