Structure information

OR4D5

PROTEIN CLASS

Class O2 (tetrapod specific odorant)

PDB CODE

8UYQ

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-024-08126-0

PUBLICATION DATE

Oct. 30, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(2R)-2-methyl-1,3-thiazolidine Y72 2.53x53 TM2 polar (hydrogen bond)
(2R)-2-methyl-1,3-thiazolidine L103 3.32x32 TM3 Van der Waals
(2R)-2-methyl-1,3-thiazolidine H104 3.33x33 TM3 Van der Waals
(2R)-2-methyl-1,3-thiazolidine G107 3.36x36 TM3 polar (hydrogen bond)
(2R)-2-methyl-1,3-thiazolidine G108 3.37x37 TM3 Van der Waals
(2R)-2-methyl-1,3-thiazolidine M111 3.40x40 TM3 polar (hydrogen bond)
(2R)-2-methyl-1,3-thiazolidine H154 4.56x56 TM4 polar (hydrogen bond)
(2R)-2-methyl-1,3-thiazolidine S202 polar (hydrogen bond)
(2R)-2-methyl-1,3-thiazolidine Y257 6.55x55 TM6 polar (hydrogen bond)
(2R)-2-methyl-1,3-thiazolidine Y274 7.41x40 TM7 Van der Waals

Ligands

(2R)-2-methyl-1,3-thiazolidine

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Residue Diagrams

L N G V V T M F Y V A S F V T F F V F R 1 G N L S F L D F C Y S S I T A P R M L V 2 V T L L F I K I G G I F H F F F L Q T L 3 C A L L M A A S W V G G F I H S I V Q I 4 Y S G L L V L F C M L T V L G N N S V M 5 A S H I A V V T L I F V P C I Y V Y T 6 A P N L M P T V I T Y L V S V A K D M 7
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ICL1 P H L H ICL1ECL1 N P T I ECL1ICL2 P L H Y T L I M ICL2ECL2 L P F C G P D K L D N F Y C D V P Q L I K L A C T D ECL2ECL3 R P F R T F P ECL3N-term M N P A N H S Q V A G F V L L G L S Q N-termC-term P I G P L E H R P L H C-term V W E L R F V F F T V F S A V Y F M T V V G N L L I V V I V T S D T T M Y F L L G N L S F L D F C Y S S I T A P R M L V D L L S G S F G G C L T Q L F F F H F I G G I K I F L L T V M A Y D R Y I A I S Q N Q T V C A L L M A A S W V G G F I H S I V Q I A L T I Q T F V L E L L M V S N N G L V T L M C F L V L L G S Y T A L L V M L R S H S R E G R S K A L S T C A S H I A V V T L I F V P C I Y V Y T M D K A V S V L Y T I V T P M L N P A I Y T L R N K E M K K K K D V I M A L W R R
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Residue Table


GPCRdb(A)
GPCRdb(A)
OR4D5
TM2
2x53 2.53x53 Y73
TM3
3x32 3.32x32 F104
3x33 3.33x33 H105
3x36 3.36x36 G108
3x37 3.37x37 G109
3x40 3.40x40 I112
TM4
4x56 4.56x56 H155
TM6
6x55 6.55x55 Y258
TM7
7x40 7.41x40 Y275