Structure information

5-HT1A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8W8B

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-023-06775-1

PUBLICATION DATE

Nov. 22, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ulotaront D116 3.32x32 TM3 polar (charge-assisted hydrogen bond)
ulotaront V117 3.33x33 TM3 hydrophobic
ulotaront V117 3.33x33 TM3 Van der Waals
ulotaront C120 3.36x36 TM3 hydrophobic
ulotaront C120 3.36x36 TM3 Van der Waals
ulotaront I189 45.52x52 ECL2 Van der Waals
ulotaront W358 6.48x48 TM6 hydrophobic
ulotaront W358 6.48x48 TM6 Van der Waals
ulotaront F361 6.51x51 TM6 hydrophobic
ulotaront F361 6.51x51 TM6 Van der Waals
ulotaront F362 6.52x52 TM6 aromatic (edge-to-face)
ulotaront F362 6.52x52 TM6 Van der Waals
ulotaront Y390 7.43x42 TM7 hydrophobic
ulotaront Y390 7.43x42 TM7 Van der Waals

Ligands

ulotaront

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Residue Diagrams

A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7
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ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM3
3x32 3.32x32 D116
3x33 3.33x33 V117
3x36 3.36x36 C120
ECL2
45x52 45.52x52 I189
TM6
6x48 6.48x48 W358
6x51 6.51x51 F361
6x52 6.52x52 F362
TM7
7x42 7.43x42 Y390