PDB
8WRZ
Resolution
3.6 Å
Released
Feb. 28, 2024
Receptor
CB1
Class
A
Species
Homo sapiens
Ligand
AM841
Function
Agonist
Reference
10.1093/PROCEL/PWAD055

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Ligand Amino Acid Generic Number Segment Interaction Type
AM841 F170 2.57x57 TM2 hydrophobic
AM841 F177 2.64x64 TM2 hydrophobic
AM841 H178 2.65x65 TM2 Van der Waals
AM841 H178 2.65x65 TM2 polar (hydrogen bond)
AM841 L193 3.29x29 TM3 Van der Waals
AM841 V196 3.32x32 TM3 Van der Waals
AM841 V196 3.32x32 TM3 hydrophobic
AM841 T197 3.33x33 TM3 polar (hydrogen bond)
AM841 F268 ECL2 hydrophobic
AM841 F268 ECL2 Van der Waals
AM841 I271 ECL2 Van der Waals
AM841 I271 ECL2 hydrophobic
AM841 Y275 5.39x39 TM5 hydrophobic
AM841 Y275 5.39x39 TM5 Van der Waals
AM841 L276 5.40x40 TM5 hydrophobic
AM841 L276 5.40x40 TM5 Van der Waals
AM841 W279 5.43x43 TM5 hydrophobic
AM841 W279 5.43x43 TM5 Van der Waals
AM841 M363 6.55x55 TM6 Van der Waals
AM841 F379 7.35x34 TM7 Van der Waals
AM841 F379 7.35x34 TM7 hydrophobic
AM841 A380 7.36x35 TM7 Van der Waals
AM841 S383 7.39x38 TM7 Van der Waals
AM841 S383 7.39x38 TM7 polar (hydrogen bond)

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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Helix box plot — Download: PNG | SVG L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7

GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x64 2.64x64 F177
2x65 2.65x65 H178
TM3
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
TM5
5x39 5.39x39 Y275
5x40 5.40x40 L276
5x43 5.43x43 W279
TM6
6x55 6.55x55 M363
TM7
7x34 7.35x34 F379
7x35 7.36x35 A380
7x38 7.39x38 S383