PDB
8WSS
Resolution
3.0 Å
Released
June 19, 2024
Receptor
MCH1
Class
A
Species
Homo sapiens
Ligand
melanin-concentrating hormone (Human)
Function
Agonist
Reference
10.1038/S41421-024-00679-8

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Ligand Amino Acid Generic Number Segment Interaction Type
melanin-concentrating hormone (Human) D192 3.32x32 TM3 polar (charge-assisted hydrogen bond)
melanin-concentrating hormone (Human) Q196 3.36x36 TM3 polar (hydrogen bond)
melanin-concentrating hormone (Human) I254 ECL2 Van der Waals
melanin-concentrating hormone (Human) I254 ECL2 hydrophobic
melanin-concentrating hormone (Human) F256 ECL2 Van der Waals
melanin-concentrating hormone (Human) F256 ECL2 hydrophobic
melanin-concentrating hormone (Human) C263 45.50x50 ECL2 Van der Waals
melanin-concentrating hormone (Human) C263 45.50x50 ECL2 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) G264 45.51x51 ECL2 Van der Waals
melanin-concentrating hormone (Human) I265 45.52x52 ECL2 Van der Waals
melanin-concentrating hormone (Human) I265 45.52x52 ECL2 hydrophobic
melanin-concentrating hormone (Human) R266 ECL2 Van der Waals
melanin-concentrating hormone (Human) D271 ECL2 Van der Waals
melanin-concentrating hormone (Human) L274 5.35x36 TM5 Van der Waals
melanin-concentrating hormone (Human) L274 5.35x36 TM5 hydrophobic
melanin-concentrating hormone (Human) Y341 6.51x51 TM6 Van der Waals
melanin-concentrating hormone (Human) Q345 6.55x55 TM6 Van der Waals
melanin-concentrating hormone (Human) Q348 6.58x58 TM6 polar (hydrogen bond)
melanin-concentrating hormone (Human) Q348 6.58x58 TM6 polar (hydrogen bond)
melanin-concentrating hormone (Human) S352 ECL3 Van der Waals
melanin-concentrating hormone (Human) R353 ECL3 Van der Waals
melanin-concentrating hormone (Human) P354 ECL3 Van der Waals
melanin-concentrating hormone (Human) V359 7.32x31 TM7 Van der Waals
melanin-concentrating hormone (Human) V359 7.32x31 TM7 hydrophobic
melanin-concentrating hormone (Human) Y362 7.35x34 TM7 polar (hydrogen bond)
melanin-concentrating hormone (Human) I366 7.39x38 TM7 Van der Waals
melanin-concentrating hormone (Human) I366 7.39x38 TM7 hydrophobic

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ICL1 K L H W C N ICL1ECL1 N G V W H F ECL1ICL2 P I S S T K F R ICL2ECL2 R L I P F P G G A V G C G I R L P N ECL2ICL3 T S S V A P A S ICL3ECL3 S R P T ECL3N-term M D L E A S L L P T G P N A S N T S D G P D N L T S A G S P P R T G S I N-termC-term P A A Q G Q L R A V S N A Q T A D E E R T E S K G T C-term S Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H K P S V A T L V I C L L W A L S F I S I T P V W L Y A P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T L V L F R K R S V K
Helix box plot — Download: PNG | SVG S N G I I G L L C I T G F V S P M I I N 1 I N L S V V D L L F L L G M P F M I H Q 2 A T L I Y T S T F Q S N A D M A T I L T 3 A T L V I C L L W A L S F I S I T P V 4 Y A A T I V V F P L A F A L F F Q Y L T F 5 I A I C L V F F V C W A P Y Y V L Q L T 6 F P N L C S N A Y G L S I A A N Y L Y 7

GPCRdb(A)
GPCRdb(A)
MCH1 receptor
TM3
3x32 3.32x32 D123
3x36 3.36x36 Q127
ECL2
45x50 45.50x50 C194
45x51 45.51x51 G195
45x52 45.52x52 I196
TM5
5x36 5.35x36 L205
TM6
6x51 6.51x51 Y272
6x55 6.55x55 Q276
6x58 6.58x58 Q279
TM7
7x31 7.32x31 V290
7x34 7.35x34 Y293
7x38 7.39x38 I297