Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WU1

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2023.11.017

PUBLICATION DATE

March 20, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MDMB-Fubinaca F170 2.57x57 TM2 hydrophobic
MDMB-Fubinaca F174 2.61x61 TM2 hydrophobic
MDMB-Fubinaca F177 2.64x64 TM2 hydrophobic
MDMB-Fubinaca L193 3.29x29 TM3 hydrophobic
MDMB-Fubinaca V196 3.32x32 TM3 hydrophobic
MDMB-Fubinaca F200 3.36x36 TM3 aromatic (face-to-face)
MDMB-Fubinaca F268 ECL2 aromatic (edge-to-face)
MDMB-Fubinaca Y275 5.39x39 TM5 hydrophobic
MDMB-Fubinaca W279 5.43x43 TM5 hydrophobic
MDMB-Fubinaca L359 6.51x51 TM6 hydrophobic
MDMB-Fubinaca F379 7.35x34 TM7 hydrophobic
MDMB-Fubinaca S383 7.39x38 TM7 polar (hydrogen bond)
MDMB-Fubinaca S383 7.39x38 TM7 Van der Waals

Ligands

MDMB-Fubinaca

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x61 2.61x61 F174
2x64 2.64x64 F177
TM3
3x29 3.29x29 L193
3x32 3.32x32 V196
3x36 3.36x36 F200
TM5
5x39 5.39x39 Y275
5x43 5.43x43 W279
TM6
6x51 6.51x51 L359
TM7
7x34 7.35x34 F379
7x38 7.39x38 S383