PDB
8WWL
Resolution
2.8 Å
Released
Nov. 13, 2024
Receptor
MCH1
Class
A
Species
Homo sapiens
Ligand
melanin-concentrating hormone (Human)
Function
Agonist
Reference
10.1038/S41421-024-00754-0

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Ligand Amino Acid Generic Number Segment Interaction Type
melanin-concentrating hormone (Human) M168 2.60x60 TM2 hydrophobic
melanin-concentrating hormone (Human) Q171 2.63x63 TM2 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) Q171 2.63x63 TM2 Van der Waals
melanin-concentrating hormone (Human) L172 2.64x64 TM2 hydrophobic
melanin-concentrating hormone (Human) L172 2.64x64 TM2 Van der Waals
melanin-concentrating hormone (Human) M173 2.65x65 TM2 Van der Waals
melanin-concentrating hormone (Human) G174 ECL1 Van der Waals
melanin-concentrating hormone (Human) G174 ECL1 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) N175 ECL1 Van der Waals
melanin-concentrating hormone (Human) G176 ECL1 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) G176 ECL1 Van der Waals
melanin-concentrating hormone (Human) T189 3.29x29 TM3 Van der Waals
melanin-concentrating hormone (Human) D192 3.32x32 TM3 polar (charge-assisted hydrogen bond)
melanin-concentrating hormone (Human) Q196 3.36x36 TM3 polar (hydrogen bond)
melanin-concentrating hormone (Human) I254 ECL2 Van der Waals
melanin-concentrating hormone (Human) I254 ECL2 hydrophobic
melanin-concentrating hormone (Human) F256 ECL2 hydrophobic
melanin-concentrating hormone (Human) F256 ECL2 Van der Waals
melanin-concentrating hormone (Human) C263 45.50x50 ECL2 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) C263 45.50x50 ECL2 Van der Waals
melanin-concentrating hormone (Human) G264 45.51x51 ECL2 Van der Waals
melanin-concentrating hormone (Human) I265 45.52x52 ECL2 polar (hydrogen bond with backbone)
melanin-concentrating hormone (Human) I265 45.52x52 ECL2 Van der Waals
melanin-concentrating hormone (Human) R266 ECL2 Van der Waals
melanin-concentrating hormone (Human) L274 5.35x36 TM5 Van der Waals
melanin-concentrating hormone (Human) L274 5.35x36 TM5 hydrophobic
melanin-concentrating hormone (Human) F277 5.38x39 TM5 hydrophobic
melanin-concentrating hormone (Human) F277 5.38x39 TM5 Van der Waals
melanin-concentrating hormone (Human) W338 6.48x48 TM6 Van der Waals
melanin-concentrating hormone (Human) Y341 6.51x51 TM6 Van der Waals
melanin-concentrating hormone (Human) Y341 6.51x51 TM6 hydrophobic
melanin-concentrating hormone (Human) Q345 6.55x55 TM6 polar (hydrogen bond)
melanin-concentrating hormone (Human) Q348 6.58x58 TM6 Van der Waals
melanin-concentrating hormone (Human) Q348 6.58x58 TM6 polar (hydrogen bond)
melanin-concentrating hormone (Human) P354 ECL3 Van der Waals
melanin-concentrating hormone (Human) P354 ECL3 hydrophobic
melanin-concentrating hormone (Human) T355 ECL3 Van der Waals
melanin-concentrating hormone (Human) L356 7.29x28 TM7 Van der Waals
melanin-concentrating hormone (Human) L356 7.29x28 TM7 hydrophobic
melanin-concentrating hormone (Human) V359 7.32x31 TM7 hydrophobic
melanin-concentrating hormone (Human) V359 7.32x31 TM7 Van der Waals
melanin-concentrating hormone (Human) Y360 7.33x32 TM7 Van der Waals
melanin-concentrating hormone (Human) Y362 7.35x34 TM7 polar (hydrogen bond)
melanin-concentrating hormone (Human) Y362 7.35x34 TM7 polar (hydrogen bond)
melanin-concentrating hormone (Human) I366 7.39x38 TM7 hydrophobic
melanin-concentrating hormone (Human) I366 7.39x38 TM7 Van der Waals
melanin-concentrating hormone (Human) Y370 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K L H W C N ICL1ECL1 N G V W H F ECL1ICL2 P I S S T K F R ICL2ECL2 R L I P F P G G A V G C G I R L P N ECL2ICL3 T S S V A P A S ICL3ECL3 S R P T ECL3N-term M D L E A S L L P T G P N A S N T S D G P D N L T S A G S P P R T G S I N-termC-term P A A Q G Q L R A V S N A Q T A D E E R T E S K G T C-term S Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H K P S V A T L V I C L L W A L S F I S I T P V W L Y A P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T L V L F R K R S V K
Helix box plot — Download: PNG | SVG S N G I I G L L C I T G F V S P M I I N 1 I N L S V V D L L F L L G M P F M I H Q 2 A T L I Y T S T F Q S N A D M A T I L T 3 A T L V I C L L W A L S F I S I T P V 4 Y A A T I V V F P L A F A L F F Q Y L T F 5 I A I C L V F F V C W A P Y Y V L Q L T 6 F P N L C S N A Y G L S I A A N Y L Y 7

GPCRdb(A)
GPCRdb(A)
MCH1 receptor
TM2
2x60 2.60x60 M99
2x63 2.63x63 Q102
2x64 2.64x64 L103
2x65 2.65x65 M104
TM3
3x29 3.29x29 T120
3x32 3.32x32 D123
3x36 3.36x36 Q127
ECL2
45x50 45.50x50 C194
45x51 45.51x51 G195
45x52 45.52x52 I196
TM5
5x36 5.35x36 L205
5x39 5.38x39 F208
TM6
6x48 6.48x48 W269
6x51 6.51x51 Y272
6x55 6.55x55 Q276
6x58 6.58x58 Q279
TM7
7x28 7.29x28 L287
7x31 7.32x31 V290
7x32 7.33x32 Y291
7x34 7.35x34 Y293
7x38 7.39x38 I297
7x42 7.43x42 Y301