PDB
8WZ2
Resolution
2.7 Å
Released
June 19, 2024
Receptor
QRFP
Class
A
Species
Homo sapiens
Ligand
26RFa
Function
Agonist
Reference
10.1038/S41421-024-00670-3

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Ligand Amino Acid Generic Number Segment Interaction Type
26RFa V35 N-term hydrophobic
26RFa C98 2.57x56 TM2 Van der Waals
26RFa C98 2.57x56 TM2 polar (hydrogen bond)
26RFa V101 2.60x59 TM2 Van der Waals
26RFa V101 2.60x59 TM2 hydrophobic
26RFa L104 2.63x62 TM2 Van der Waals
26RFa L104 2.63x62 TM2 hydrophobic
26RFa Q105 2.64x63 TM2 polar (hydrogen bond)
26RFa Q105 2.64x63 TM2 polar (hydrogen bond)
26RFa S108 2.67x66 TM2 Van der Waals
26RFa D109 ECL1 Van der Waals
26RFa N110 23.49x49 ECL1 Van der Waals
26RFa W111 23.50x50 ECL1 Van der Waals
26RFa W111 23.50x50 ECL1 aromatic (edge-to-face)
26RFa C118 3.25x25 TM3 Van der Waals
26RFa P122 3.29x29 TM3 hydrophobic
26RFa P122 3.29x29 TM3 Van der Waals
26RFa Q125 3.32x32 TM3 Van der Waals
26RFa S126 3.33x33 TM3 Van der Waals
26RFa V129 3.36x36 TM3 Van der Waals
26RFa V129 3.36x36 TM3 hydrophobic
26RFa Q184 4.64x64 TM4 Van der Waals
26RFa Q184 4.64x64 TM4 polar (hydrogen bond)
26RFa C200 ECL2 polar (hydrogen bond)
26RFa C201 45.50x50 ECL2 Van der Waals
26RFa C201 45.50x50 ECL2 polar (hydrogen bond with backbone)
26RFa L202 45.51x51 ECL2 Van der Waals
26RFa L202 45.51x51 ECL2 hydrophobic
26RFa E203 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
26RFa Y214 5.38x39 TM5 Van der Waals
26RFa Y214 5.38x39 TM5 hydrophobic
26RFa T215 5.39x40 TM5 polar (hydrogen bond)
26RFa F289 6.51x51 TM6 hydrophobic
26RFa F289 6.51x51 TM6 Van der Waals
26RFa H293 6.55x55 TM6 Van der Waals
26RFa Q318 7.39x38 TM7 polar (hydrogen bond)
26RFa Q318 7.39x38 TM7 Van der Waals
26RFa F322 7.43x42 TM7 Van der Waals

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ICL1 K A M R ICL1ECL1 D N W L G G A ECL1ICL2 P F K M K W Q Y ICL2ECL2 Q L E I K Y D F L Y E K E H I C C L E E W T ECL2ICL3 H G K E ICL3ECL3 N F E K E Y D ECL3N-term M Q A L N I T P E Q F S R L L R D H N L T R E Q F I A L Y R L R P L V Y T P E L N-termC-term N K T F S P A Q R H G N S G I T M M R K K A K F S L R E N P V E E T K G E A F S D G N I E V K L C E Q T E E K K K L K R H L A L F R S E L A E N S P L D S G H C-term P G R A K L A L V L T G V L I F A L A L F G N A L V F Y V V T R S T V T N I F I C S L A L S D L L I T F F C I P V T M L Q N I S F I C K M V P F V Q S T A V V T E I L T M T C I A V E R H Q G L V H T N R R A F T M L G V V W L V A V I V G S P M W H V Q S P V H Q K I Y T T F I L V I L F L L P L M V M L I L Y S K I G Y E L W I K K R V G D G S V L R T I M S K I A R K K K R A V I M M V T V V A L F A V C W A P F H V V H M M I E Y S D V T I K M I F A I V Q I I G F S N S I C N P I V Y A F M N E N V L S C I V F K K N A V C Y
Helix box plot — Download: PNG | SVG A N G F L A L A F I L V G T L V L A L K 1 C S L A L S D L L I T F F C I P V T M L Q 2 C T M T L I E T V V A T S Q V F P V M K 3 A F T M L G V V W L V A V I V G S P M W 4 Y L I L M V M L P L L F L I V L I F T T Y 5 V T V V A L F A V C W A P F H V V H M M 6 I P N C I S N S F G I I Q V I A F I M 7

GPCRdb(A)
GPCRdb(A)
QRFP receptor
TM2
2x56 2.57x56 C98
2x59 2.60x59 V101
2x62 2.63x62 L104
2x63 2.64x63 Q105
2x66 2.67x66 S108
ECL1
23x49 23.49x49 N110
23x50 23.50x50 W111
TM3
3x25 3.25x25 C118
3x29 3.29x29 P122
3x32 3.32x32 Q125
3x33 3.33x33 S126
3x36 3.36x36 V129
TM4
4x64 4.64x64 Q184
ECL2
45x50 45.50x50 C201
45x51 45.51x51 L202
45x52 45.52x52 E203
TM5
5x39 5.38x39 Y214
5x40 5.39x40 T215
TM6
6x51 6.51x51 F289
6x55 6.55x55 H293
TM7
7x38 7.39x38 Q318
7x42 7.43x42 F322