PDB
8X0D
Resolution
3.5 Å
Released
Nov. 6, 2024
Receptor
mGlu5
Class
C
Species
Homo sapiens
Ligands
Function
VU0424465
Ago-PAM
quisqualate
Agonist
Reference
10.1038/S41467-024-55439-9
VU0424465 quisqualate

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Ligand Amino Acid Generic Number Segment Interaction Type
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate W100 N-term aromatic (edge-to-face)
quisqualate G150 N-term Van der Waals
quisqualate S151 N-term Van der Waals
quisqualate S152 N-term polar (hydrogen bond)
quisqualate S152 N-term polar (hydrogen bond with backbone)
quisqualate S173 N-term polar (hydrogen bond with backbone)
quisqualate A174 N-term Van der Waals
quisqualate T175 N-term Van der Waals
quisqualate Y223 N-term aromatic (pi-cation)
quisqualate E279 N-term Van der Waals
quisqualate G280 N-term Van der Waals
quisqualate G306 N-term Van der Waals
quisqualate R310 N-term polar (charge-charge)
quisqualate K396 N-term Van der Waals
VU0424465 G624 2.45x45 TM2 Van der Waals
VU0424465 I625 2.46x46 TM2 hydrophobic
VU0424465 S654 3.39x39 TM3 Van der Waals
VU0424465 P655 3.40x40 TM3 hydrophobic
VU0424465 S658 3.43x43 TM3 Van der Waals
VU0424465 Y659 3.44x44 TM3 aromatic (edge-to-face)
VU0424465 L744 5.44x44 TM5 Van der Waals
VU0424465 W785 6.50x50 TM6 polar (hydrogen bond with backbone)
VU0424465 W785 6.50x50 TM6 aromatic (face-to-face)
VU0424465 W785 6.50x50 TM6 hydrophobic
VU0424465 F788 6.53x53 TM6 hydrophobic
VU0424465 V789 6.54x54 TM6 hydrophobic
VU0424465 Y792 6.57x57 TM6 hydrophobic
VU0424465 M802 7.32x33 TM7 hydrophobic
VU0424465 S805 7.35x36 TM7 polar (hydrogen bond)
VU0424465 S805 7.35x36 TM7 polar (hydrogen bond)
VU0424465 V806 7.36x37 TM7 hydrophobic
VU0424465 S809 7.39x40 TM7 Van der Waals
VU0424465 A810 7.40x41 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu5 receptor
TM2
2x49 2.45x45 G624
2x50 2.46x46 I625
TM3
3x35 3.39x39 S654
3x36 3.40x40 P655
3x39 3.43x43 S658
3x40 3.44x44 Y659
TM5
5x44 5.44x44 L744
TM6
6x48 6.50x50 W785
6x51 6.53x53 F788
6x52 6.54x54 V789
6x55 6.57x57 Y792
TM7
7x38 7.32x33 M802
7x41 7.35x36 S805
7x42 7.36x37 V806
7x45 7.39x40 S809
7x46 7.40x41 A810