PDB
8X0F
Resolution
3.3 Å
Released
Nov. 6, 2024
Receptor
mGlu5
Class
C
Species
Homo sapiens
Ligands
Function
VU-29
PAM
quisqualate
Agonist
Reference
10.1038/S41467-024-55439-9
VU-29 quisqualate

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Ligand Amino Acid Generic Number Segment Interaction Type
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate W100 N-term aromatic (edge-to-face)
quisqualate G150 N-term Van der Waals
quisqualate S151 N-term Van der Waals
quisqualate S152 N-term polar (hydrogen bond)
quisqualate S173 N-term polar (hydrogen bond with backbone)
quisqualate T175 N-term polar (hydrogen bond)
quisqualate Y223 N-term aromatic (pi-cation)
quisqualate E279 N-term Van der Waals
quisqualate G280 N-term polar (hydrogen bond with backbone)
quisqualate D305 N-term polar (charge-charge)
quisqualate D305 N-term polar (hydrogen bond)
quisqualate G306 N-term Van der Waals
quisqualate R310 N-term polar (charge-charge)
quisqualate K396 N-term Van der Waals
VU-29 I651 3.36x36 TM3 hydrophobic
VU-29 P655 3.40x40 TM3 hydrophobic
VU-29 S658 3.43x43 TM3 Van der Waals
VU-29 Y659 3.44x44 TM3 Van der Waals
VU-29 V740 5.40x40 TM5 Van der Waals
VU-29 L744 5.44x44 TM5 hydrophobic
VU-29 T781 6.46x46 TM6 hydrophobic
VU-29 I784 6.49x49 TM6 hydrophobic
VU-29 W785 6.50x50 TM6 hydrophobic
VU-29 W785 6.50x50 TM6 aromatic (edge-to-face)
VU-29 F788 6.53x53 TM6 hydrophobic
VU-29 V789 6.54x54 TM6 Van der Waals
VU-29 Y792 6.57x57 TM6 aromatic (edge-to-face)
VU-29 M802 7.32x33 TM7 hydrophobic
VU-29 V806 7.36x37 TM7 Van der Waals
VU-29 S809 7.39x40 TM7 Van der Waals
VU-29 A810 7.40x41 TM7 Van der Waals
VU-29 L813 7.43x44 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

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ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu5 receptor
TM3
3x32 3.36x36 I651
3x36 3.40x40 P655
3x39 3.43x43 S658
3x40 3.44x44 Y659
TM5
5x40 5.40x40 V740
5x44 5.44x44 L744
TM6
6x44 6.46x46 T781
6x47 6.49x49 I784
6x48 6.50x50 W785
6x51 6.53x53 F788
6x52 6.54x54 V789
6x55 6.57x57 Y792
TM7
7x38 7.32x33 M802
7x42 7.36x37 V806
7x45 7.39x40 S809
7x46 7.40x41 A810
7x49 7.43x44 A813