Structure information

mGlu5 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

8X0H

SPECIES

Homo sapiens

RESOLUTION

4.100

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-024-55439-9

PUBLICATION DATE

Nov. 6, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
quisqualate Y64 N-term Van der Waals
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate W100 N-term Van der Waals
quisqualate W100 N-term aromatic (edge-to-face)
quisqualate S152 N-term Van der Waals
quisqualate S173 N-term polar (hydrogen bond with backbone)
quisqualate S173 N-term Van der Waals
quisqualate T175 N-term polar (hydrogen bond)
quisqualate T175 N-term polar (hydrogen bond with backbone)
quisqualate Y223 N-term polar (hydrogen bond)
quisqualate Y223 N-term Van der Waals
quisqualate E279 N-term Van der Waals
quisqualate G280 N-term polar (hydrogen bond with backbone)
quisqualate G280 N-term Van der Waals
quisqualate G306 N-term Van der Waals
quisqualate R310 N-term polar (charge-assisted hydrogen bond)
quisqualate K396 N-term Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 18 of 18 entries

Ligands

quisqualate

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Residue Diagrams

L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu5 receptor