PDB
8X2K
Resolution
3.0 Å
Released
April 3, 2024
Receptor
GPR3
Class
A
Species
Homo sapiens
Ligand
Function
N-oleoylethanolamide
Agonist
Reference
10.1038/S41422-023-00919-8

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Ligand Amino Acid Generic Number Segment Interaction Type
N-oleoylethanolamide V113 3.29x29 TM3 hydrophobic
N-oleoylethanolamide L116 3.32x32 TM3 Van der Waals
N-oleoylethanolamide A117 3.33x33 TM3 Van der Waals
N-oleoylethanolamide F120 3.36x36 TM3 Van der Waals
N-oleoylethanolamide T121 3.37x37 TM3 hydrophobic
N-oleoylethanolamide I124 3.40x40 TM3 hydrophobic
N-oleoylethanolamide G125 3.41x41 TM3 Van der Waals
N-oleoylethanolamide L159 4.48x48 TM4 Van der Waals
N-oleoylethanolamide V160 4.49x49 TM4 Van der Waals
N-oleoylethanolamide V187 ECL2 Van der Waals
N-oleoylethanolamide L198 5.43x43 TM5 hydrophobic
N-oleoylethanolamide A201 5.46x46 TM5 hydrophobic
N-oleoylethanolamide F202 5.47x47 TM5 hydrophobic
N-oleoylethanolamide V205 5.50x50 TM5 Van der Waals
N-oleoylethanolamide W260 6.48x48 TM6 hydrophobic
N-oleoylethanolamide F263 6.51x51 TM6 hydrophobic
N-oleoylethanolamide L283 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P A F R ICL1ECL1 C I G ECL1ICL2 A L T Y Y ICL2ECL2 V L A W N C L D G L T T C G V V Y P L ECL2ICL3 H L ICL3ECL3 D A H S ECL3N-term M M W G A G S P L A W L S A G S G N V N V S S V G P A E G P T G P A A P L P S P N-termC-term C C S S S K I P F R S R S P S D V C-term K A W D V V L C I S G T L V S C E N A L V V A I I V G T A P M F L L V G S L A V A D L L A G L G L V L H F A A V F S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N S E T T V T R T Y V M L A L V W G G A L G L G L L P S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R L P A S H Y V A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D L W A V Q K V V C C
Helix box plot — Download: PNG | SVG A N E C S V L T G S I C L V V D W A K 1 G S L A V A D L L A G L G L V L H F A A 2 A L L S G I S A T F A M A L V G V L V L 3 T Y V M L A L V W G G A L G L G L L P 4 Y L Q L M I G F V M F F A I A L V V L H 5 A V V L G A F A A C W L P F T V Y C L L 6 I P N I M S N Y T A P L L T L Y T Y L 7

GPCRdb(A)
GPCRdb(A)
GPR3
TM3
3x29 3.29x29 V113
3x32 3.32x32 L116
3x33 3.33x33 A117
3x36 3.36x36 F120
3x37 3.37x37 T121
3x40 3.40x40 I124
3x41 3.41x41 G125
TM4
4x48 4.48x48 L159
4x49 4.49x49 V160
TM5
5x43 5.43x43 L198
5x46 5.46x46 A201
5x47 5.47x47 F202
5x50 5.50x50 V205
TM6
6x48 6.48x48 W260
6x51 6.51x51 F263
TM7
7x38 7.39x38 L283