Structure information

H1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X64

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

B

REFERENCE

10.1038/S41467-023-44477-4

PUBLICATION DATE

Jan. 17, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
desloratadine D107 3.32x32 TM3 polar (charge-assisted hydrogen bond)
desloratadine Y108 3.33x33 TM3 aromatic (edge-to-face)
desloratadine Y108 3.33x33 TM3 Van der Waals
desloratadine S111 3.36x36 TM3 Van der Waals
desloratadine I115 3.40x40 TM3 hydrophobic
desloratadine T194 5.42x43 TM5 Van der Waals
desloratadine N198 5.46x461 TM5 Van der Waals
desloratadine W428 6.48x48 TM6 hydrophobic
desloratadine W428 6.48x48 TM6 Van der Waals
desloratadine Y431 6.51x51 TM6 polar (hydrogen bond)
desloratadine Y431 6.51x51 TM6 Van der Waals
desloratadine F432 6.52x52 TM6 aromatic (edge-to-face)
desloratadine F432 6.52x52 TM6 Van der Waals
desloratadine F435 6.55x55 TM6 hydrophobic
desloratadine F435 6.55x55 TM6 Van der Waals
desloratadine Y458 7.43x42 TM7 Van der Waals

Ligands

desloratadine

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Residue Diagrams

L N L G V T V L C I T S L V V V L P 1 V S L S V A D L I V G V A V M P M N I L Y 2 I F V S F I S A T S A V Y D M S L W F L 3 A S A T I L G A W F L S F L W V I P I 4 Y F W L M L L T P L Y F N I I A T M V K F 5 G F I M A A F I L C W I P Y F I F F M V 6 L P N L T S N I Y G L W I T F M H L H 7
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ICL1 R K L H ICL1ECL1 S K W S L ECL1ICL2 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
H1 receptor
TM3
3x32 3.32x32 D107
3x33 3.33x33 Y108
3x36 3.36x36 S111
3x40 3.40x40 I115
TM5
5x43 5.42x43 T194
5x461 5.46x461 N198
TM6
6x48 6.48x48 W428
6x51 6.51x51 Y431
6x52 6.52x52 F432
6x55 6.55x55 F435
TM7
7x42 7.43x42 Y458