Structure information

SST5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X8L

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

June 12, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Cortistatin Y89 2.53x53 TM2 polar (charge-assisted hydrogen bond)
Cortistatin Y89 2.53x53 TM2 polar (hydrogen bond)
Cortistatin L96 2.60x60 TM2 Van der Waals
Cortistatin Q99 2.63x63 TM2 polar (hydrogen bond)
Cortistatin N100 2.64x64 TM2 polar (hydrogen bond)
Cortistatin S103 ECL1 Van der Waals
Cortistatin M116 3.29x29 TM3 Van der Waals
Cortistatin D119 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Cortistatin Q123 3.36x36 TM3 polar (hydrogen bond)
Cortistatin F124 3.37x37 TM3 Van der Waals
Cortistatin L174 4.60x61 TM4 Van der Waals
Cortistatin G184 ECL2 Van der Waals
Cortistatin T185 ECL2 polar (hydrogen bond)
Cortistatin T185 ECL2 polar (hydrogen bond)
Cortistatin C186 45.50x50 ECL2 polar (hydrogen bond with backbone)
Cortistatin C186 45.50x50 ECL2 Van der Waals
Cortistatin N187 45.51x51 ECL2 polar (hydrogen bond)
Cortistatin N187 45.51x51 ECL2 polar (hydrogen bond)
Cortistatin A188 45.52x52 ECL2 hydrophobic
Cortistatin A188 45.52x52 ECL2 Van der Waals
Cortistatin W190 ECL2 polar (hydrogen bond)
Cortistatin W190 ECL2 aromatic (edge-to-face)
Cortistatin G198 5.35x36 TM5 polar (hydrogen bond with backbone)
Cortistatin G198 5.35x36 TM5 Van der Waals
Cortistatin F201 5.38x39 TM5 Van der Waals
Cortistatin F201 5.38x39 TM5 hydrophobic
Cortistatin I202 5.39x40 TM5 polar (hydrogen bond)
Cortistatin T205 5.42x43 TM5 Van der Waals
Cortistatin F264 6.51x51 TM6 aromatic (edge-to-face)
Cortistatin F264 6.51x51 TM6 polar (hydrogen bond)
Cortistatin F265 6.52x52 TM6 Van der Waals
Cortistatin N268 6.55x55 TM6 polar (hydrogen bond)
Cortistatin N271 6.58x58 TM6 polar (hydrogen bond)
Cortistatin E279 ECL3 polar (charge-assisted hydrogen bond)
Cortistatin A283 7.32x31 TM7 Van der Waals
Cortistatin A283 7.32x31 TM7 polar (hydrogen bond with backbone)
Cortistatin Y286 7.35x34 TM7 hydrophobic
Cortistatin Y286 7.35x34 TM7 Van der Waals
Cortistatin F287 7.36x35 TM7 polar (hydrogen bond)
Cortistatin V290 7.39x38 TM7 polar (hydrogen bond)
Cortistatin V290 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Cortistatin Y294 7.43x42 TM7 polar (charge-assisted hydrogen bond)
Cortistatin Y294 7.43x42 TM7 polar (hydrogen bond)

Ligands

Cortistatin

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Residue Diagrams

T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7
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ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x53 2.53x53 Y89
2x60 2.60x60 L96
2x63 2.63x63 Q99
2x64 2.64x64 N100
TM3
3x29 3.29x29 M116
3x32 3.32x32 D119
3x36 3.36x36 Q123
3x37 3.37x37 F124
TM4
4x61 4.60x61 L174
ECL2
45x50 45.50x50 C186
45x51 45.51x51 N187
45x52 45.52x52 A188
TM5
5x36 5.35x36 G198
5x39 5.38x39 F201
5x40 5.39x40 I202
5x43 5.42x43 T205
TM6
6x51 6.51x51 F264
6x52 6.52x52 F265
6x55 6.55x55 N268
6x58 6.58x58 N271
TM7
7x31 7.32x31 A283
7x34 7.35x34 Y286
7x35 7.36x35 F287
7x38 7.39x38 V290
7x42 7.43x42 Y294