PDB
8X9S
Resolution
3.5 Å
Released
Feb. 12, 2025
Receptor
ADGRD1
Class
B2
Species
Homo sapiens
Ligand
Function
dihydrotestosterone
Agonist
Reference
10.1016/J.CELL.2025.01.006

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Ligand Amino Acid Generic Number Segment Interaction Type
dihydrotestosterone L619 2.64x64 TM2 hydrophobic
dihydrotestosterone F623 2.68x68 TM2 Van der Waals
dihydrotestosterone W705 45.51x51 ECL2 hydrophobic
dihydrotestosterone W773 6.53x53 TM6 Van der Waals
dihydrotestosterone F791 7.42x41 TM7 Van der Waals
dihydrotestosterone N795 7.46x45 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 S T I R ICL1ECL1 E P G ECL1ICL2 V F G S E D S ICL2ECL2 M D S Y G T S N N C W L S L A S ECL2ICL3 I H G ICL3ECL3 N G ECL3N-term M E K L L R L C C W Y S W L L L F Y Y N F Q V R G V Y S R S Q D H P G F Q V L A S A S H Y W P L E N V D G I H E L Q D T T G D I V E G K V N K G I Y L K E E K G V T L L Y Y G R Y N S S C I S K P E Q C G P E G V T F S F F W K T Q G E Q S R P I P S A Y G G Q V I S N G F K V C S S G G R G S V E L Y T R D N S M T W E A S F S P P G P Y W T H V L F T W K S K E G L K V Y V N G T L S T S D P S G K V S R D Y G E S N V N L V I G S E Q D Q A K C Y E N G A F D E F I I W E R A L T P D E I A M Y F T A A I G K H A L L S S T L P S L F M T S T A S P V M P T D A N-termC-term T S S S A R T S N A K P F H S D L M N G T R P G M A S T K L S P W D K S S H S A H R V D L S A V C-term A R G H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K K H R Y Y Y G M G W G F P L L I C I I S L S F A G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D N Y K D P S A F K L T A K A V A V L L P I L G T S W V F G V L A V C A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E F K H W S L V R A A K T K V
Helix box plot — Download: PNG | SVG V L C L V S L S C G V Y S I S S L A V Q 1 A N L S F A V L V A Q V L L L I S F R L 2 V L M W A F A S L F F Y H L L V A M V Q 3 K H R Y Y Y G G M W G F P L L I C I I S L 4 L I G I N V V I V F L A P A V F A W I A 5 A V L L P I L G T S W V F G V L A V 6 L F I F L G Q L S N L T A F M Y Q F V 7

GPCRdb(A)
GPCRdb(B)
ADGRD1
TM2
2x57 2.64x64 L619
2x61 2.68x68 F623
ECL2
45x51 45.51x51 W705
TM6
6x48 6.53x53 W773
TM7
7x37 7.42x41 F791
7x41 7.46x45 N795