Structure information

kisspeptin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XGS

SPECIES

Homo sapiens

RESOLUTION

2.950

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ADN7771

PUBLICATION DATE

Oct. 30, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Kisspeptin-10 C95 2.57x56 TM2 Van der Waals
Kisspeptin-10 C95 2.57x56 TM2 polar (hydrogen bond)
Kisspeptin-10 T99 2.61x60 TM2 Van der Waals
Kisspeptin-10 T99 2.61x60 TM2 polar (hydrogen bond)
Kisspeptin-10 L102 ECL1 Van der Waals
Kisspeptin-10 L102 ECL1 hydrophobic
Kisspeptin-10 Y103 ECL1 Van der Waals
Kisspeptin-10 P106 ECL1 Van der Waals
Kisspeptin-10 V118 3.28x28 TM3 hydrophobic
Kisspeptin-10 N119 3.29x29 TM3 Van der Waals
Kisspeptin-10 Q122 3.32x32 TM3 polar (hydrogen bond)
Kisspeptin-10 Q122 3.32x32 TM3 Van der Waals
Kisspeptin-10 Q123 3.33x33 TM3 polar (hydrogen bond)
Kisspeptin-10 Q123 3.33x33 TM3 Van der Waals
Kisspeptin-10 V126 3.36x36 TM3 Van der Waals
Kisspeptin-10 V126 3.36x36 TM3 hydrophobic
Kisspeptin-10 H181 ECL2 polar (hydrogen bond)
Kisspeptin-10 Y190 ECL2 hydrophobic
Kisspeptin-10 Y190 ECL2 Van der Waals
Kisspeptin-10 F204 5.38x39 TM5 Van der Waals
Kisspeptin-10 L283 6.55x55 TM6 hydrophobic
Kisspeptin-10 L283 6.55x55 TM6 Van der Waals
Kisspeptin-10 R297 ECL3 Van der Waals
Kisspeptin-10 Y299 7.29x28 TM7 hydrophobic
Kisspeptin-10 Y299 7.29x28 TM7 Van der Waals
Kisspeptin-10 K305 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Kisspeptin-10 H309 7.39x38 TM7 Van der Waals
Kisspeptin-10 Y313 7.43x42 TM7 polar (hydrogen bond)
Kisspeptin-10 Y313 7.43x42 TM7 Van der Waals

Ligands

Kisspeptin-10

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Residue Diagrams

S N G V L G L L M L A A F F L P V L W A 1 A N L A A T D V T F L C L C V P F T A L L 2 A T L T A C T A Q V S V Q Q I Y N V F K 3 A L A V S L S I W V G S A A V S A P V 4 Y C A C T A L L P L L Y L A L L N Y L A F 5 A A V V L L F A A C W G P I Q L F L V L 6 L P N L A S N S Y S M C H A W T K L A 7
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ICL1 K P M R ICL1ECL1 P L P G W V L ECL1ICL2 P L R A L H R R ICL2ECL2 R L S P G P R A Y C S E A F P ECL2ECL3 P A G S W H P R ECL3N-term M H T V A T S G P N A S W G A P A N A S G C P G C G A N A S D G P V P S P R N-termC-term C A P R R P R R P R R P G P S D P A A P H A E L L R L G S H P A P A R A Q K P G S S G L A A R G L C V L G E D N A P L C-term A V D A W L V P L F F A A L M L L G L V G N S L V I Y V I C R H T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y G D F M C K F V N Y I Q Q V S V Q A T C A T L T A M S V D R W Y V T V F T P R L A L A V S L S I W V G S A A V S A P V L A L H S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V A V R P A P A D S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R R F R Q A V C P
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Residue Table


GPCRdb(A)
GPCRdb(A)
kisspeptin receptor
TM2
2x56 2.57x56 C95
2x60 2.61x60 T99
TM3
3x28 3.28x28 V118
3x29 3.29x29 N119
3x32 3.32x32 Q122
3x33 3.33x33 Q123
3x36 3.36x36 V126
TM5
5x39 5.38x39 F204
TM6
6x55 6.55x55 L283
TM7
7x28 7.29x28 Y299
7x34 7.35x34 K305
7x38 7.39x38 H309
7x42 7.43x42 Y313