Structure information

kisspeptin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XGU

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ADN7771

PUBLICATION DATE

Oct. 30, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 C95 2.57x56 TM2 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 C95 2.57x56 TM2 polar (hydrogen bond)
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 F98 2.60x59 TM2 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 T99 2.61x60 TM2 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 L102 ECL1 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 L102 ECL1 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y103 ECL1 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 G107 23.49x49 ECL1 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 V118 3.28x28 TM3 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 N119 3.29x29 TM3 polar (hydrogen bond)
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Q122 3.32x32 TM3 polar (hydrogen bond)
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Q123 3.33x33 TM3 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Q123 3.33x33 TM3 polar (hydrogen bond)
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 V126 3.36x36 TM3 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 V126 3.36x36 TM3 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y190 ECL2 polar (hydrogen bond)
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 C191 45.50x50 ECL2 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 F195 ECL2 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 F204 5.38x39 TM5 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 F204 5.38x39 TM5 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 N208 5.42x43 TM5 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 I279 6.51x51 TM6 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 I279 6.51x51 TM6 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Q280 6.52x52 TM6 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 F282 6.54x54 TM6 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 F282 6.54x54 TM6 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 L283 6.55x55 TM6 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 L283 6.55x55 TM6 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Q286 6.58x58 TM6 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 P296 ECL3 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 P296 ECL3 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 R297 ECL3 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 S298 7.28x27 TM7 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y299 7.29x28 TM7 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y299 7.29x28 TM7 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 A301 7.31x30 TM7 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y302 7.32x31 TM7 hydrophobic
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y302 7.32x31 TM7 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 K305 7.35x34 TM7 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 H309 7.39x38 TM7 polar (hydrogen bond)
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 H309 7.39x38 TM7 Van der Waals
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y313 7.43x42 TM7 polar (hydrogen bond)
ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2 Y313 7.43x42 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 43 of 43 entries

Ligands

ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2

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Residue Diagrams

S N G V L G L L M L A A F F L P V L W A 1 A N L A A T D V T F L C L C V P F T A L L 2 A T L T A C T A Q V S V Q Q I Y N V F K 3 A L A V S L S I W V G S A A V S A P V 4 Y C A C T A L L P L L Y L A L L N Y L A F 5 A A V V L L F A A C W G P I Q L F L V L 6 L P N L A S N S Y S M C H A W T K L A 7
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ICL1 ECL1 ICL2 ECL2 ECL3 N-term C-term A V D A W L V P L F F A A L M L L G L V G N S L V I Y V I C R H T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y G D F M C K F V N Y I Q Q V S V Q A T C A T L T A M S V D R W Y V T V F T P R L A L A V S L S I W V G S A A V S A P V L A L H S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V A V R P A P A D S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R R F R Q A V C P
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Residue Table


GPCRdb(A)
GPCRdb(A)
kisspeptin receptor
TM2
2x56 2.57x56 C95
2x59 2.60x59 F98
2x60 2.61x60 T99
ECL1
23x49 23.49x49 G107
TM3
3x28 3.28x28 V118
3x29 3.29x29 N119
3x32 3.32x32 Q122
3x33 3.33x33 Q123
3x36 3.36x36 V126
ECL2
45x50 45.50x50 C191
TM5
5x39 5.38x39 F204
5x43 5.42x43 N208
TM6
6x51 6.51x51 I279
6x52 6.52x52 Q280
6x54 6.54x54 F282
6x55 6.55x55 L283
6x58 6.58x58 Q286
TM7
7x27 7.28x27 S298
7x28 7.29x28 Y299
7x30 7.31x30 A301
7x31 7.32x31 Y302
7x34 7.35x34 K305
7x38 7.39x38 H309
7x42 7.43x42 Y313