Structure information

SST1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XIO

SPECIES

Homo sapiens

RESOLUTION

2.650

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

July 3, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide L114 2.60x60 TM2 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide L134 3.29x29 TM3 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide A138 3.33x33 TM3 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide M141 3.36x36 TM3 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide I192 4.60x61 TM4 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide M210 45.52x52 ECL2 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide F223 5.38x39 TM5 aromatic (edge-to-face)
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide W284 6.48x48 TM6 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide F287 6.51x51 TM6 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide Q291 6.55x55 TM6 polar (hydrogen bond)
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide Q291 6.55x55 TM6 Van der Waals
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide V309 7.39x38 TM7 hydrophobic
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide V309 7.39x38 TM7 Van der Waals
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide Y313 7.43x42 TM7 Van der Waals
(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide Y313 7.43x42 TM7 aromatic (face-to-face)

Ligands

(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide

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Residue Diagrams

S N G C L G V L C V V S Y I F S I L I A 1 L N L A I A D E L L M L S V P F L V T S 2 V T L C Y I S T F M N V A D V S L V L R 3 A K V V N L G V W V L S L L V I L P I 4 Y C L C I A G V P L L F G M L F T Y L V F 5 M M V V M V F V I C W M P F Y V V Q L V 6 I P N A C S N A Y G L I V S L Q S V T 7
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ICL1 A K M K ICL1ECL1 R H W P F ECL1ICL2 P I K A A R Y R ICL2ECL2 R T A A N S D G T V A C N M L M P E ECL2ICL3 W Q Q R K R S ICL3ECL3 E Q D ECL3N-term M F P N G T A S S P S S S P S P S P G S C G E G G G S R G P G A G A A D G M E E P G R N A S Q N G T L S N-termC-term L S W M D N A A E E P V D Y Y A T A L K S R A Y S V E D F Q P E N L E S G G V F R N G T C T S R I T T L C-term E G Q G S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H R P T V A K V V N L G V W V L S L L V I L P I V V F S P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G E R K I T L M V M M V V M V F V I C W M P F Y V V Q L V N V F A D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F Q R F K R S I L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST1 receptor
TM2
2x60 2.60x60 L114
TM3
3x29 3.29x29 L134
3x33 3.33x33 A138
3x36 3.36x36 M141
TM4
4x61 4.60x61 I192
ECL2
45x52 45.52x52 M210
TM5
5x39 5.38x39 F223
TM6
6x48 6.48x48 W284
6x51 6.51x51 F287
6x55 6.55x55 Q291
TM7
7x38 7.39x38 V309
7x42 7.43x42 Y313