PDB
8XIP
Resolution
3.3 Å
Released
July 3, 2024
Receptor
SST1
Class
A
Species
Homo sapiens
Ligand
Function
pasireotide
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
pasireotide S110 2.56x56 TM2 Van der Waals
pasireotide F113 2.59x59 TM2 hydrophobic
pasireotide L114 2.60x60 TM2 hydrophobic
pasireotide S117 2.63x63 TM2 Van der Waals
pasireotide V133 3.28x28 TM3 hydrophobic
pasireotide L134 3.29x29 TM3 hydrophobic
pasireotide D137 3.32x32 TM3 polar (hydrogen bond)
pasireotide D137 3.32x32 TM3 polar (charge-charge)
pasireotide D137 3.32x32 TM3 hydrophobic
pasireotide A138 3.33x33 TM3 Van der Waals
pasireotide M141 3.36x36 TM3 hydrophobic
pasireotide F142 3.37x37 TM3 hydrophobic
pasireotide C208 45.50x50 ECL2 Van der Waals
pasireotide N209 45.51x51 ECL2 hydrophobic
pasireotide M210 45.52x52 ECL2 hydrophobic
pasireotide L220 5.35x36 TM5 hydrophobic
pasireotide T227 5.42x43 TM5 hydrophobic
pasireotide F287 6.51x51 TM6 Van der Waals
pasireotide Q291 6.55x55 TM6 polar (hydrogen bond)
pasireotide D300 ECL3 polar (hydrogen bond)
pasireotide D300 ECL3 polar (charge-charge)
pasireotide D301 ECL3 Van der Waals
pasireotide A302 ECL3 Van der Waals
pasireotide T303 ECL3 Van der Waals
pasireotide S305 7.35x34 TM7 Van der Waals
pasireotide Q306 7.36x35 TM7 Van der Waals
pasireotide V309 7.39x38 TM7 Van der Waals
pasireotide Y313 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 R H W P F ECL1ICL2 P I K A A R Y R ICL2ECL2 R T A A N S D G T V A C N M L M P E ECL2ICL3 W Q Q R K R S ICL3ECL3 E Q D ECL3N-term M F P N G T A S S P S S S P S P S P G S C G E G G G S R G P G A G A A D G M E E P G R N A S Q N G T L S N-termC-term L S W M D N A A E E P V D Y Y A T A L K S R A Y S V E D F Q P E N L E S G G V F R N G T C T S R I T T L C-term E G Q G S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H R P T V A K V V N L G V W V L S L L V I L P I V V F S P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G E R K I T L M V M M V V M V F V I C W M P F Y V V Q L V N V F A D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F Q R F K R S I L C
Helix box plot — Download: PNG | SVG S N G C L G V L C V V S Y I F S I L I A 1 L N L A I A D E L L M L S V P F L V T S 2 V T L C Y I S T F M N V A D V S L V L R 3 A K V V N L G V W V L S L L V I L P I 4 Y C L C I A G V P L L F G M L F T Y L V F 5 M M V V M V F V I C W M P F Y V V Q L V 6 I P N A C S N A Y G L I V S L Q S V T 7

GPCRdb(A)
GPCRdb(A)
SST1 receptor
TM2
2x56 2.56x56 S110
2x59 2.59x59 F113
2x60 2.60x60 L114
2x63 2.63x63 S117
TM3
3x28 3.28x28 V133
3x29 3.29x29 L134
3x32 3.32x32 D137
3x33 3.33x33 A138
3x36 3.36x36 M141
3x37 3.37x37 F142
ECL2
45x50 45.50x50 C208
45x51 45.51x51 N209
45x52 45.52x52 M210
TM5
5x36 5.35x36 L220
5x43 5.42x43 T227
TM6
6x51 6.51x51 F287
6x55 6.55x55 Q291
TM7
7x34 7.35x34 S305
7x35 7.36x35 Q306
7x38 7.39x38 V309
7x42 7.43x42 Y313