PDB
8XJL
Resolution
2.8 Å
Released
Feb. 28, 2024
Receptor
FP
Class
A
Species
Homo sapiens
Ligand
PGF2α
Function
Agonist
Reference
10.1016/J.CELREP.2024.113893

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Ligand Amino Acid Generic Number Segment Interaction Type
PGF2α S33 1.39x39 TM1 polar (hydrogen bond)
PGF2α S33 1.39x39 TM1 Van der Waals
PGF2α F36 1.42x42 TM1 Van der Waals
PGF2α H81 2.54x54 TM2 Van der Waals
PGF2α H81 2.54x54 TM2 polar (hydrogen bond)
PGF2α N84 2.57x57 TM2 Van der Waals
PGF2α G85 2.58x58 TM2 Van der Waals
PGF2α Y92 2.65x65 TM2 polar (hydrogen bond)
PGF2α Y92 2.65x65 TM2 Van der Waals
PGF2α M115 3.32x32 TM3 hydrophobic
PGF2α M115 3.32x32 TM3 Van der Waals
PGF2α S118 3.35x35 TM3 Van der Waals
PGF2α G119 3.36x36 TM3 Van der Waals
PGF2α T184 ECL2 Van der Waals
PGF2α T184 ECL2 polar (hydrogen bond)
PGF2α W185 ECL2 hydrophobic
PGF2α W185 ECL2 Van der Waals
PGF2α W262 6.48x48 TM6 hydrophobic
PGF2α W262 6.48x48 TM6 Van der Waals
PGF2α L287 7.36x35 TM7 hydrophobic
PGF2α L287 7.36x35 TM7 Van der Waals
PGF2α L290 7.39x38 TM7 hydrophobic
PGF2α L290 7.39x38 TM7 Van der Waals
PGF2α R291 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGF2α T294 7.43x42 TM7 polar (hydrogen bond)
PGF2α T294 7.43x42 TM7 Van der Waals
PGF2α Q297 7.46x46 TM7 polar (hydrogen bond)
PGF2α Q297 7.46x46 TM7 Van der Waals

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ICL1 K S K ICL1ECL1 K E W I R F D Q S ECL1ICL2 P I F H S T K I ICL2ECL2 H R D Y K I Q A S R T W C F Y N T E D I K ECL2ICL3 Q H R Q G ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C Q T E N R L S N-termC-term I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K C C G V L K N L A S Q V H V
Helix box plot — Download: PNG | SVG S N S L I G V T M F I V S F F V 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7

GPCRdb(A)
GPCRdb(A)
FP receptor
TM1
1x39 1.39x39 S33
1x42 1.42x42 F36
TM2
2x54 2.54x54 H81
2x57 2.57x57 N84
2x58 2.58x58 G85
2x65 2.65x65 Y92
TM3
3x32 3.32x32 M115
3x35 3.35x35 S118
3x36 3.36x36 G119
TM6
6x48 6.48x48 W262
TM7
7x35 7.36x35 L287
7x38 7.39x38 L290
7x39 7.40x39 R291
7x42 7.43x42 T294
7x46 7.46x46 Q297