PDB
8XQR
Resolution
3.2 Å
Released
July 10, 2024
Receptor
TAS2R14
Class
T2
Species
Homo sapiens
Ligand
Function
flufenamic acid
Allosteric agonist
Reference
10.1038/S41586-024-07569-9

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Ligand Amino Acid Generic Number Segment Interaction Type
flufenamic acid G104 3.47x47 TM3 Van der Waals
flufenamic acid Y107 3.50x50 TM3 hydrophobic
flufenamic acid Y107 3.50x50 TM3 aromatic (edge-to-face)
flufenamic acid S194 5.54x54 TM5 polar (hydrogen bond)
flufenamic acid M197 5.57x57 TM5 Van der Waals
flufenamic acid F198 5.58x58 TM5 aromatic (edge-to-face)
flufenamic acid F198 5.58x58 TM5 hydrophobic
flufenamic acid L201 5.61x61 TM5 hydrophobic
flufenamic acid I202 5.62x62 TM5 Van der Waals
flufenamic acid V230 6.35x35 TM6 Van der Waals
flufenamic acid F237 6.42x42 TM6 Van der Waals
flufenamic acid H276 7.49x49 TM7 polar (hydrogen bond)
flufenamic acid L280 7.53x53 TM7 Van der Waals
flufenamic acid G283 7.56x56 TM7 Van der Waals

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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
Helix box plot — Download: PNG | SVG S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7

GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x47 3.47x47 G104
3x50 3.50x50 Y107
TM5
5x54 5.54x54 S194
5x57 5.57x57 M197
5x58 5.58x58 F198
5x61 5.61x61 L201
5x62 5.62x62 I202
TM6
6x35 6.35x35 V230
6x42 6.42x42 F237
TM7
7x49 7.49x49 H276
7x53 7.53x53 L280
7x56 7.56x56 G283