PDB
8XVK
Resolution
3.2 Å
Released
Aug. 28, 2024
Receptor
ETA
Class
A
Species
Homo sapiens
Ligand
ambrisentan
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
ambrisentan F161 3.28x28 TM3 aromatic (edge-to-face)
ambrisentan P162 3.29x29 TM3 hydrophobic
ambrisentan Q165 3.32x32 TM3 Van der Waals
ambrisentan Q165 3.32x32 TM3 polar (hydrogen bond)
ambrisentan K166 3.33x33 TM3 polar (charge-assisted hydrogen bond)
ambrisentan V169 3.36x36 TM3 hydrophobic
ambrisentan V169 3.36x36 TM3 Van der Waals
ambrisentan L259 5.42x43 TM5 hydrophobic
ambrisentan L259 5.42x43 TM5 Van der Waals
ambrisentan W319 6.48x48 TM6 hydrophobic
ambrisentan W319 6.48x48 TM6 Van der Waals
ambrisentan L322 6.51x51 TM6 hydrophobic
ambrisentan L322 6.51x51 TM6 Van der Waals
ambrisentan H323 6.52x52 TM6 Van der Waals
ambrisentan R326 6.55x55 TM6 Van der Waals
ambrisentan I355 7.39x38 TM7 Van der Waals
ambrisentan I355 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K C M R ICL1ECL1 G R W P F D H ECL1ICL2 W S R V Q G I G ICL2ECL2 V M V P F E Y R G E Q H K T C M L N A T ECL2ICL3 L R I A L ICL3ECL3 N E M D K N ECL3N-term M E T L C L R A S F W L A L V G C V I S D N P E R Y S T N L S N H V D D F T T F R G T E L S F L V T T H Q P T N L V L P S N G S M H N Y C N-termC-term C C Y Q S K S L M T S V P M N G T S I Q W K N H D Q N N H N T D R S S H K D S M N C-term P Q Q T K I T S A F K Y I N T V I S C T I F I V G M V G N A T L L R I I Y Q N N G P N A L I A S L A L G D L I Y V V I D L P I N V F K L L A N D F G V F L C K L F P F L Q K S S V G I T V L N L C A L S V D R Y R A V A S I P L V T A I E I V S I W I L S F I L A I P E A I G F S K F M E F Y Q D V K D W W L F G F Y F C M P L V C T A I F Y T L M T C E M L N R R N G S S E H L K Q R R E V A K T V F C L V V I F A L C W F P L H L S R I L K K T V Y R C E L L S F L L L M D Y I G I N L A T M N S C I N P I A L Y F V S K K F Q S F K N C C L C C
Helix box plot — Download: PNG | SVG A N G V M G V I F I T C S I V T N I Y K 1 A S L A L G D L I Y V I V D L P I N V F K 2 A C L N L V T I G V S S K Q L F P F L K 3 T A I E I V S I W I L S F I L A I P E 4 Y F I A T C V L P M C F Y F G F L W W D K 5 F C L V V I F A L C W F P L H L S R I L 6 I P N I C S N M T A L N I G I Y D M L 7

GPCRdb(A)
GPCRdb(A)
ETA receptor
TM3
3x28 3.28x28 F161
3x29 3.29x29 P162
3x32 3.32x32 Q165
3x33 3.33x33 K166
3x36 3.36x36 V169
TM5
5x43 5.42x43 L259
TM6
6x48 6.48x48 W319
6x51 6.51x51 L322
6x52 6.52x52 H323
6x55 6.55x55 R326
TM7
7x38 7.39x38 I355