PDB
8XVL
Resolution
3.2 Å
Released
Aug. 28, 2024
Receptor
ETA
Class
A
Species
Homo sapiens
Ligand
zibotentan
Function
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
zibotentan K140 2.64x63 TM2 polar (charge-assisted hydrogen bond)
zibotentan W146 23.50x50 ECL1 Van der Waals
zibotentan Q165 3.32x32 TM3 Van der Waals
zibotentan K166 3.33x33 TM3 polar (charge-assisted hydrogen bond)
zibotentan F224 ECL2 Van der Waals
zibotentan L259 5.42x43 TM5 hydrophobic
zibotentan L259 5.42x43 TM5 Van der Waals
zibotentan W319 6.48x48 TM6 Van der Waals
zibotentan W319 6.48x48 TM6 aromatic (edge-to-face)
zibotentan L322 6.51x51 TM6 hydrophobic
zibotentan L322 6.51x51 TM6 Van der Waals
zibotentan R326 6.55x55 TM6 Van der Waals
zibotentan I355 7.39x38 TM7 hydrophobic
zibotentan I355 7.39x38 TM7 Van der Waals
zibotentan T359 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K C M R ICL1ECL1 G R W P F D H ECL1ICL2 W S R V Q G I G ICL2ECL2 V M V P F E Y R G E Q H K T C M L N A T ECL2ICL3 L R I A L ICL3ECL3 N E M D K N ECL3N-term M E T L C L R A S F W L A L V G C V I S D N P E R Y S T N L S N H V D D F T T F R G T E L S F L V T T H Q P T N L V L P S N G S M H N Y C N-termC-term C C Y Q S K S L M T S V P M N G T S I Q W K N H D Q N N H N T D R S S H K D S M N C-term P Q Q T K I T S A F K Y I N T V I S C T I F I V G M V G N A T L L R I I Y Q N N G P N A L I A S L A L G D L I Y V V I D L P I N V F K L L A N D F G V F L C K L F P F L Q K S S V G I T V L N L C A L S V D R Y R A V A S I P L V T A I E I V S I W I L S F I L A I P E A I G F S K F M E F Y Q D V K D W W L F G F Y F C M P L V C T A I F Y T L M T C E M L N R R N G S S E H L K Q R R E V A K T V F C L V V I F A L C W F P L H L S R I L K K T V Y R C E L L S F L L L M D Y I G I N L A T M N S C I N P I A L Y F V S K K F Q S F K N C C L C C
Helix box plot — Download: PNG | SVG A N G V M G V I F I T C S I V T N I Y K 1 A S L A L G D L I Y V I V D L P I N V F K 2 A C L N L V T I G V S S K Q L F P F L K 3 T A I E I V S I W I L S F I L A I P E 4 Y F I A T C V L P M C F Y F G F L W W D K 5 F C L V V I F A L C W F P L H L S R I L 6 I P N I C S N M T A L N I G I Y D M L 7

GPCRdb(A)
GPCRdb(A)
ETA receptor
TM2
2x63 2.64x63 K140
ECL1
23x50 23.50x50 W146
TM3
3x32 3.32x32 Q165
3x33 3.33x33 K166
TM5
5x43 5.42x43 L259
TM6
6x48 6.48x48 W319
6x51 6.51x51 L322
6x55 6.55x55 R326
TM7
7x38 7.39x38 I355
7x42 7.43x42 T359