Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XZF

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2024.02.004

PUBLICATION DATE

March 20, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
WN561 W85 2.60x60 TM2 hydrophobic
WN561 Y88 2.63x63 TM2 Van der Waals
WN561 Y88 2.63x63 TM2 polar (hydrogen bond)
WN561 Y93 ECL1 hydrophobic
WN561 Y93 ECL1 Van der Waals
WN561 I109 3.32x32 TM3 Van der Waals
WN561 I109 3.32x32 TM3 hydrophobic
WN561 F110 3.33x33 TM3 hydrophobic
WN561 F110 3.33x33 TM3 Van der Waals
WN561 L160 4.56x56 TM4 Van der Waals
WN561 L160 4.56x56 TM4 hydrophobic
WN561 P163 4.59x60 TM4 Van der Waals
WN561 P163 4.59x60 TM4 hydrophobic
WN561 R168 4.64x65 TM4 polar (charge-assisted hydrogen bond)
WN561 Q180 ECL2 Van der Waals
WN561 C181 45.50x50 ECL2 Van der Waals
WN561 Y182 45.51x51 ECL2 hydrophobic
WN561 Y182 45.51x51 ECL2 Van der Waals
WN561 M183 45.52x52 ECL2 Van der Waals
WN561 M183 45.52x52 ECL2 polar (hydrogen bond with backbone)
WN561 D184 ECL2 Van der Waals
WN561 Y185 ECL2 Van der Waals
WN561 Y185 ECL2 hydrophobic
WN561 E194 5.31x32 TM5 Van der Waals
WN561 L201 5.38x39 TM5 polar (hydrogen bond with backbone)
WN561 L201 5.38x39 TM5 Van der Waals
WN561 G202 5.39x40 TM5 Van der Waals
WN561 S205 5.42x43 TM5 Van der Waals
WN561 Y264 6.51x51 TM6 polar (hydrogen bond)
WN561 K268 6.55x55 TM6 Van der Waals
WN561 Y271 6.58x58 TM6 polar (hydrogen bond)
WN561 Y271 6.58x58 TM6 Van der Waals
WN561 M288 7.32x31 TM7 Van der Waals
WN561 M288 7.32x31 TM7 polar (hydrogen bond with backbone)
WN561 T295 7.39x38 TM7 Van der Waals
WN561 Y299 7.43x42 TM7 Van der Waals
WN561 Y299 7.43x42 TM7 hydrophobic

Ligands

WN561

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
2x63 2.63x63 Y88
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
TM4
4x56 4.56x56 L160
4x60 4.59x60 P163
4x65 4.64x65 R168
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM5
5x32 5.31x32 E194
5x39 5.38x39 L201
5x40 5.39x40 G202
5x43 5.42x43 S205
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x31 7.32x31 M288
7x38 7.39x38 T295
7x42 7.43x42 Y299