Structure information
apelin receptorPROTEIN CLASS
Class A (Rhodopsin)
PDB CODE
8XZJ
SPECIES
Homo sapiens
RESOLUTION
3.000
PREFERRED CHAIN
R
REFERENCEPUBLICATION DATE
March 20, 2024
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Ligand Interaction Browser
Download list in excel| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
| WN353 | D23 | N-term | polar (charge-assisted hydrogen bond) | |
| WN353 | Y35 | 1.39x39 | TM1 | Van der Waals |
| WN353 | W85 | 2.60x60 | TM2 | hydrophobic |
| WN353 | W85 | 2.60x60 | TM2 | Van der Waals |
| WN353 | Y88 | 2.63x63 | TM2 | Van der Waals |
| WN353 | Y88 | 2.63x63 | TM2 | polar (hydrogen bond) |
| WN353 | Y93 | ECL1 | Van der Waals | |
| WN353 | Y93 | ECL1 | polar (hydrogen bond) | |
| WN353 | S106 | 3.29x29 | TM3 | Van der Waals |
| WN353 | I109 | 3.32x32 | TM3 | hydrophobic |
| WN353 | I109 | 3.32x32 | TM3 | Van der Waals |
| WN353 | F110 | 3.33x33 | TM3 | Van der Waals |
| WN353 | V164 | 4.60x61 | TM4 | Van der Waals |
| WN353 | V164 | 4.60x61 | TM4 | hydrophobic |
| WN353 | R168 | 4.64x65 | TM4 | polar (charge-assisted hydrogen bond) |
| WN353 | Q180 | ECL2 | polar (hydrogen bond) | |
| WN353 | Q180 | ECL2 | polar (hydrogen bond) | |
| WN353 | C181 | 45.50x50 | ECL2 | Van der Waals |
| WN353 | Y182 | 45.51x51 | ECL2 | hydrophobic |
| WN353 | Y182 | 45.51x51 | ECL2 | Van der Waals |
| WN353 | M183 | 45.52x52 | ECL2 | polar (hydrogen bond with backbone) |
| WN353 | M183 | 45.52x52 | ECL2 | Van der Waals |
| WN353 | Y185 | ECL2 | polar (hydrogen bond) | |
| WN353 | Y185 | ECL2 | Van der Waals | |
| WN353 | E194 | 5.31x32 | TM5 | Van der Waals |
| WN353 | W195 | 5.32x33 | TM5 | Van der Waals |
| WN353 | E198 | 5.35x36 | TM5 | Van der Waals |
| WN353 | K268 | 6.55x55 | TM6 | Van der Waals |
| WN353 | Y271 | 6.58x58 | TM6 | Van der Waals |
| WN353 | Y271 | 6.58x58 | TM6 | polar (hydrogen bond) |
| WN353 | M272 | 6.59x59 | TM6 | Van der Waals |
| WN353 | M272 | 6.59x59 | TM6 | hydrophobic |
| WN353 | F291 | 7.35x34 | TM7 | hydrophobic |
| WN353 | F291 | 7.35x34 | TM7 | Van der Waals |
| WN353 | P292 | 7.36x35 | TM7 | hydrophobic |
| WN353 | P292 | 7.36x35 | TM7 | Van der Waals |
| WN353 | T295 | 7.39x38 | TM7 | Van der Waals |
Ligands
WN353
Residue Diagrams
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Residue Table
|
GPCRdb(A)
|
GPCRdb(A)
|
apelin receptor
|
|---|---|---|
| TM1 | ||
| 1x39 | 1.39x39 | Y35 |
| TM2 | ||
| 2x60 | 2.60x60 | W85 |
| 2x63 | 2.63x63 | Y88 |
| TM3 | ||
| 3x29 | 3.29x29 | S106 |
| 3x32 | 3.32x32 | I109 |
| 3x33 | 3.33x33 | F110 |
| TM4 | ||
| 4x61 | 4.60x61 | V164 |
| 4x65 | 4.64x65 | R168 |
| ECL2 | ||
| 45x50 | 45.50x50 | C181 |
| 45x51 | 45.51x51 | Y182 |
| 45x52 | 45.52x52 | M183 |
| TM5 | ||
| 5x32 | 5.31x32 | E194 |
| 5x33 | 5.32x33 | W195 |
| 5x36 | 5.35x36 | E198 |
| TM6 | ||
| 6x55 | 6.55x55 | K268 |
| 6x58 | 6.58x58 | Y271 |
| 6x59 | 6.59x59 | M272 |
| TM7 | ||
| 7x34 | 7.35x34 | F291 |
| 7x35 | 7.36x35 | P292 |
| 7x38 | 7.39x38 | T295 |