PDB
8Y0N
Resolution
3.1 Å
Released
Feb. 26, 2025
Receptor
CXCR3
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL2221034
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL2221034 L102 2.53x53 TM2 hydrophobic
CHEMBL2221034 W109 2.60x60 TM2 Van der Waals
CHEMBL2221034 W117 23.50x50 ECL1 Van der Waals
CHEMBL2221034 G128 3.29x29 TM3 Van der Waals
CHEMBL2221034 F131 3.32x32 TM3 aromatic (pi-cation)
CHEMBL2221034 F131 3.32x32 TM3 hydrophobic
CHEMBL2221034 F135 3.36x36 TM3 hydrophobic
CHEMBL2221034 F135 3.36x36 TM3 aromatic (edge-to-face)
CHEMBL2221034 W268 6.48x48 TM6 aromatic (edge-to-face)
CHEMBL2221034 Y271 6.51x51 TM6 hydrophobic
CHEMBL2221034 Y271 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL2221034 S304 7.39x38 TM7 Van der Waals
CHEMBL2221034 G307 7.42x41 TM7 Van der Waals
CHEMBL2221034 Y308 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
Helix box plot — Download: PNG | SVG G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7

GPCRdb(A)
GPCRdb(A)
CXCR3
TM2
2x53 2.53x53 L102
2x60 2.60x60 W109
ECL1
23x50 23.50x50 W117
TM3
3x29 3.29x29 G128
3x32 3.32x32 F131
3x36 3.36x36 F135
TM6
6x48 6.48x48 W268
6x51 6.51x51 Y271
TM7
7x38 7.39x38 S304
7x41 7.42x41 G307
7x42 7.43x42 Y308