Structure information

BB3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8Y53

SPECIES

Homo sapiens

RESOLUTION

2.930

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Sept. 11, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MK-5046 C100 2.57x56 TM2 polar (hydrogen bond)
MK-5046 V103 2.60x59 TM2 Van der Waals
MK-5046 S124 3.29x29 TM3 polar (hydrogen bond)
MK-5046 R127 3.32x32 TM3 polar (charge-assisted hydrogen bond)
MK-5046 L128 3.33x33 TM3 Van der Waals
MK-5046 V131 3.36x36 TM3 Van der Waals
MK-5046 E182 4.60x61 TM4 polar (charge-assisted hydrogen bond)
MK-5046 S205 45.52x52 ECL2 polar (hydrogen bond)
MK-5046 C221 5.42x43 TM5 polar (hydrogen bond)
MK-5046 W284 6.48x48 TM6 aromatic (edge-to-face)
MK-5046 N287 6.51x51 TM6 polar (hydrogen bond with backbone)
MK-5046 N287 6.51x51 TM6 polar (hydrogen bond)
MK-5046 H288 6.52x52 TM6 polar (hydrogen bond)
MK-5046 Y291 6.55x55 TM6 hydrophobic
MK-5046 Y291 6.55x55 TM6 Van der Waals
MK-5046 R316 7.39x38 TM7 Van der Waals
MK-5046 A319 7.42x41 TM7 Van der Waals
MK-5046 F320 7.43x42 TM7 Van der Waals

Ligands

MK-5046

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Residue Diagrams

A N G L I G V S I I V A Y T I Y I A C L 1 T S L A F G D L L L L T L C V P V D A T H 2 I T L T F V S V G V S T L R I F S L V K 3 T C V K A G C V W I V S M I F A L P E 4 Y Y V S I I S L P I I Y F V L F C L L S H 5 L V L V A L F A L C W L P N H L L Y L Y 6 F P N V C S N S F A L V R S F I T F I 7
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ICL1 K S M Q ICL1ECL1 E G W L F ECL1ICL2 P L E R Q P S N ICL2ECL2 N V Y T F R D P N K N M T F E S C T S Y P V S ECL2ICL3 P T E E Q S ICL3ECL3 Q T Y V D P ECL3N-term M A Q R Q P H S P N Q T L I S I T N D T E S S S S V V S N D N T N K G W S G D N S P G N-termC-term C C K A E R P E P P V A D T S L T T L A V M G T V P G T G S I Q M S E I S V T S F T G C S V K Q A E D R F C-term I E A L C A I Y I T Y A V I I S V G I L G N A I L I K V F F K T T V P N I F I T S L A F G D L L L L L T C V P V D A T H Y L A G R I G C K V L S F I R L T S V G V S V F T L T I L S A D R Y K A V V K A I L K T C V K A G C V W I V S M I F A L P E A I F S K K L L Q E I H S L L C F L V F Y I I P L S I I S V Y Y S L I A R T L Y K S T L N I H A R K Q I E S R K R I A R T V L V L V A L F A L C W L P N H L L Y L Y H S F T S S A M H F I F T I F S R V L A F S N S C V N P F A L Y W L S K S F K A F Q K H Q L F
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Residue Table


GPCRdb(A)
GPCRdb(A)
BB3 receptor
TM2
2x56 2.57x56 C100
2x59 2.60x59 V103
TM3
3x29 3.29x29 S124
3x32 3.32x32 R127
3x33 3.33x33 L128
3x36 3.36x36 V131
TM4
4x61 4.60x61 E182
ECL2
45x52 45.52x52 S205
TM5
5x43 5.42x43 C221
TM6
6x48 6.48x48 W284
6x51 6.51x51 N287
6x52 6.52x52 H288
6x55 6.55x55 Y291
TM7
7x38 7.39x38 R316
7x41 7.42x41 A319
7x42 7.43x42 F320