PDB
8Y6W
Resolution
3.2 Å
Released
April 2, 2025
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligands
CHEMBL4176503
AMG7703
Function
Agonist
Ago-PAM
Reference
—
CHEMBL4176503 AMG7703

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4176503 F87 3.30x30 TM3 hydrophobic
CHEMBL4176503 Y90 3.33x33 TM3 aromatic (edge-to-face)
CHEMBL4176503 C141 4.57x57 TM4 hydrophobic
CHEMBL4176503 V144 4.60x60 TM4 hydrophobic
CHEMBL4176503 Y165 45.51x51 ECL2 hydrophobic
CHEMBL4176503 F168 ECL2 hydrophobic
CHEMBL4176503 V175 5.34x35 TM5 hydrophobic
CHEMBL4176503 V176 5.35x36 TM5 hydrophobic
CHEMBL4176503 V179 5.38x39 TM5 hydrophobic
CHEMBL4176503 R180 5.39x40 TM5 polar (charge-assisted hydrogen bond)
CHEMBL4176503 L183 5.42x43 TM5 Van der Waals
AMG7703 L229 6.42x43 TM6 hydrophobic
AMG7703 N230 6.43x44 TM6 polar (hydrogen bond)
AMG7703 N230 6.43x44 TM6 polar (hydrogen bond)
AMG7703 V233 6.46x461 TM6 hydrophobic
AMG7703 V233 6.46x461 TM6 Van der Waals
CHEMBL4176503 Y238 6.51x51 TM6 Van der Waals
CHEMBL4176503 R255 7.35x34 TM7 polar (charge-assisted hydrogen bond)
AMG7703 L264 7.44x43 TM7 hydrophobic
AMG7703 L264 7.44x43 TM7 Van der Waals
AMG7703 L268 7.48x48 TM7 hydrophobic
AMG7703 L268 7.48x48 TM7 Van der Waals

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Download PDB file

Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM3
3x30 3.30x30 F87
3x33 3.33x33 Y90
TM4
4x57 4.57x57 C141
4x60 4.60x60 V144
ECL2
45x51 45.51x51 Y165
TM5
5x35 5.34x35 V175
5x36 5.35x36 V176
5x39 5.38x39 V179
5x40 5.39x40 R180
5x43 5.42x43 L183
TM6
6x43 6.42x43 L229
6x44 6.43x44 N230
6x461 6.46x461 V233
6x51 6.51x51 Y238
TM7
7x34 7.35x34 R255
7x43 7.44x43 L264
7x48 7.48x48 L268