PDB
8Y6Y
Resolution
3.4 Å
Released
April 2, 2025
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligand
GLPG0974
Function
Allosteric antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
GLPG0974 C82 3.25x25 TM3 hydrophobic
GLPG0974 S86 3.29x29 TM3 polar (hydrogen bond with backbone)
GLPG0974 S86 3.29x29 TM3 Van der Waals
GLPG0974 F89 3.32x32 TM3 Van der Waals
GLPG0974 F89 3.32x32 TM3 aromatic (face-to-face)
GLPG0974 T163 ECL2 Van der Waals
GLPG0974 C164 45.50x50 ECL2 Van der Waals
GLPG0974 Y344 6.51x51 TM6 Van der Waals
GLPG0974 R361 7.35x34 TM7 Van der Waals
GLPG0974 V365 7.39x38 TM7 hydrophobic
GLPG0974 V365 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM3
3x25 3.25x25 C82
3x29 3.29x29 S86
3x32 3.32x32 F89
ECL2
45x50 45.50x50 C164
TM6
6x51 6.51x51 Y238
TM7
7x34 7.35x34 R255
7x38 7.39x38 V259