PDB
8Y72
Resolution
2.7 Å
Released
Aug. 6, 2025
Receptor
μ
Class
A
Species
Homo sapiens
Ligands
BMS-986122
DAMGO
Function
PAM
Agonist
Reference
10.1126/SCIADV.AEA9832
BMS-986122 DAMGO

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Ligand Amino Acid Generic Number Segment Interaction Type
BMS-986122 Y108 2.42x42 TM2 polar (hydrogen bond)
DAMGO W135 23.50x50 ECL1 hydrophobic
DAMGO V145 3.28x28 TM3 hydrophobic
DAMGO I146 3.29x29 TM3 hydrophobic
DAMGO D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
DAMGO Y150 3.33x33 TM3 Van der Waals
DAMGO M153 3.36x36 TM3 hydrophobic
DAMGO M153 3.36x36 TM3 Van der Waals
BMS-986122 F158 3.41x41 TM3 aromatic (face-to-edge)
BMS-986122 F158 3.41x41 TM3 Van der Waals
BMS-986122 C161 3.44x44 TM3 Van der Waals
BMS-986122 T162 3.45x45 TM3 polar (hydrogen bond)
BMS-986122 T162 3.45x45 TM3 polar (hydrogen bond with backbone)
BMS-986122 V165 3.48x48 TM3 hydrophobic
BMS-986122 V165 3.48x48 TM3 Van der Waals
BMS-986122 D166 3.49x49 TM3 polar (hydrogen bond with backbone)
BMS-986122 D166 3.49x49 TM3 polar (charge-assisted hydrogen bond)
BMS-986122 I189 4.45x45 TM4 hydrophobic
BMS-986122 I189 4.45x45 TM4 Van der Waals
BMS-986122 N193 4.49x49 TM4 polar (hydrogen bond)
BMS-986122 L196 4.52x52 TM4 Van der Waals
DAMGO T220 45.51x51 ECL2 polar (hydrogen bond)
DAMGO L221 45.52x52 ECL2 Van der Waals
DAMGO V238 5.42x43 TM5 hydrophobic
DAMGO V238 5.42x43 TM5 Van der Waals
BMS-986122 F241 5.45x46 TM5 Van der Waals
BMS-986122 F241 5.45x46 TM5 hydrophobic
BMS-986122 M245 5.49x49 TM5 Van der Waals
BMS-986122 M245 5.49x49 TM5 hydrophobic
DAMGO I298 6.51x51 TM6 hydrophobic
DAMGO I298 6.51x51 TM6 Van der Waals
DAMGO H299 6.52x52 TM6 Van der Waals
DAMGO W320 7.35x34 TM7 hydrophobic
DAMGO W320 7.35x34 TM7 Van der Waals
DAMGO I324 7.39x38 TM7 Van der Waals
DAMGO I324 7.39x38 TM7 hydrophobic
DAMGO Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x42 2.42x42 Y108
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
3x41 3.41x41 F158
3x44 3.44x44 C161
3x45 3.45x45 T162
3x48 3.48x48 V165
3x49 3.49x49 D166
TM4
4x45 4.45x45 I189
4x49 4.49x49 N193
4x52 4.52x52 L196
ECL2
45x51 45.51x51 T220
45x52 45.52x52 L221
TM5
5x43 5.42x43 V238
5x46 5.45x46 F241
5x49 5.49x49 M245
TM6
6x51 6.51x51 I298
6x52 6.52x52 H299
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328