PDB
8YFO
Resolution
2.7 Å
Released
Sept. 3, 2025
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
Function
Ac-LA-PTH
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
Ac-LA-PTH V31 N-term Van der Waals
Ac-LA-PTH M32 N-term Van der Waals
Ac-LA-PTH T33 N-term Van der Waals
Ac-LA-PTH E35 N-term hydrophobic
Ac-LA-PTH E36 N-term hydrophobic
Ac-LA-PTH Y145 N-term hydrophobic
Ac-LA-PTH E180 1.32x32 TM1 Van der Waals
Ac-LA-PTH R181 1.33x33 TM1 aromatic (pi-cation)
Ac-LA-PTH F184 1.36x36 TM1 hydrophobic
Ac-LA-PTH D185 1.37x37 TM1 polar (charge-charge)
Ac-LA-PTH Y195 1.47x47 TM1 polar (hydrogen bond)
Ac-LA-PTH R233 2.60x60 TM2 polar (charge-charge)
Ac-LA-PTH I237 2.64x64 TM2 Van der Waals
Ac-LA-PTH K240 2.67x67 TM2 hydrophobic
Ac-LA-PTH Y245 2.72x72 TM2 hydrophobic
Ac-LA-PTH Y245 2.72x72 TM2 aromatic (pi-cation)
Ac-LA-PTH F288 3.36x36 TM3 hydrophobic
Ac-LA-PTH L289 3.37x37 TM3 hydrophobic
Ac-LA-PTH L292 3.40x40 TM3 hydrophobic
Ac-LA-PTH Y296 3.44x44 TM3 Van der Waals
Ac-LA-PTH D353 45.52x52 ECL2 Van der Waals
Ac-LA-PTH L354 ECL2 hydrophobic
Ac-LA-PTH S355 ECL2 Van der Waals
Ac-LA-PTH K360 5.36x37 TM5 Van der Waals
Ac-LA-PTH W361 5.37x38 TM5 Van der Waals
Ac-LA-PTH I363 5.39x39 TM5 hydrophobic
Ac-LA-PTH Q364 5.40x40 TM5 Van der Waals
Ac-LA-PTH L368 5.44x44 TM5 hydrophobic
Ac-LA-PTH M425 6.57x57 TM6 Van der Waals
Ac-LA-PTH Y429 ECL3 hydrophobic
Ac-LA-PTH T430 ECL3 polar (hydrogen bond with backbone)
Ac-LA-PTH V432 ECL3 Van der Waals
Ac-LA-PTH W437 7.35x34 TM7 polar (hydrogen bond)
Ac-LA-PTH Q440 7.38x37 TM7 Van der Waals
Ac-LA-PTH M441 7.39x38 TM7 hydrophobic
Ac-LA-PTH E444 7.42x41 TM7 hydrophobic
Ac-LA-PTH M445 7.43x42 TM7 hydrophobic
Ac-LA-PTH N448 7.46x45 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x28 1.32x32 E180
1x29 1.33x33 R181
1x32 1.36x36 F184
1x33 1.37x37 D185
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x57 2.64x64 I237
2x60 2.67x67 K240
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
3x40 3.44x44 Y296
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x42 5.37x38 W361
5x43 5.39x39 I363
5x44 5.40x40 Q364
5x48 5.44x44 L368
TM6
6x52 6.57x57 M425
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448