PDB
8YH5
Resolution
3.7 Å
Released
Nov. 6, 2024
Receptor
A3
Class
A
Species
Ovis aries
Ligand
Riboprine
Function
Agonist
Reference
10.1038/S41467-024-53473-1

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Ligand Amino Acid Generic Number Segment Interaction Type
Riboprine M90 3.32x32 TM3 hydrophobic
Riboprine F167 45.52x52 ECL2 hydrophobic
Riboprine M173 ECL2 hydrophobic
Riboprine L252 6.58x58 TM6 hydrophobic
Riboprine L263 7.35x34 TM7 hydrophobic
Riboprine I267 7.39x38 TM7 hydrophobic
Riboprine H271 7.43x42 TM7 polar (hydrogen bond)
Riboprine H271 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P S L Q ICL1ECL1 V T I ECL1ICL2 T V R Y R R V T ICL2ECL2 W N M K L S S A D E N L T F L P C R F R S V M R M D Y M V Y F ECL2ECL3 D G Q V ECL3N-term M P V N S T A V N-termC-term Q P S K S M D P S T E Q T S E C-term S W T S V T Y I T V E I L I G L C A I V G N V L V I W V V K L N T T T F Y F I V S L A L A D I A V G V L V M P L A I V I S L G H F Y S C L F M T C L M L I F T H A S I M S L L A I A V D R Y L R V K L T Q R R I W L A L G L C W L V S F L V G L T P M F G S F F L W I L V P L V V M C A I Y F D I F Y I I R N R L S Q S F S G S R E T G A F Y G R E F K T A K S L L L V L F L F A L C W L P L S I I N C I L Y F P Q T V L Y L G I L L S H A N S M M N P I V Y A Y K I K K F L L I V M C K E T Y L K A C
Helix box plot — Download: PNG | SVG V N G V I A C L G I L I E V T I Y T V S 1 V S L A L A D I A V G L V V M P L A I V I 2 A L L S M I S A H T F I L M L C T M F L 3 I W L A L G L C W L V S F L V G L T P M 4 Y I A C M V V L P V L I W L F F S 5 L L V L F L F A L C W L P L S I I N C I 6 I P N M M S N A H S L L I G L Y L V T 7

GPCRdb(A)
GPCRdb(A)
A3 receptor
TM3
3x32 3.32x32 M90
ECL2
45x52 45.52x52 F167
TM6
6x58 6.58x58 L252
TM7
7x34 7.35x34 L263
7x38 7.39x38 I267
7x42 7.43x42 H271