PDB
8YIC
Resolution
3.5 Å
Released
Dec. 11, 2024
Receptor
S1P1
Class
A
Species
Homo sapiens
Ligand
Function
SAR247799
Agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
SAR247799 K34 N-term polar (charge-charge)
SAR247799 N101 2.60x60 TM2 Van der Waals
SAR247799 T108 23.49x49 ECL1 Van der Waals
SAR247799 R120 3.28x28 TM3 polar (charge-charge)
SAR247799 E121 3.29x29 TM3 Van der Waals
SAR247799 M124 3.32x32 TM3 Van der Waals
SAR247799 F125 3.33x33 TM3 aromatic (face-to-face)
SAR247799 L128 3.36x36 TM3 hydrophobic
SAR247799 S129 3.37x37 TM3 Van der Waals
SAR247799 L174 4.56x56 TM4 Van der Waals
SAR247799 V194 ECL2 Van der Waals
SAR247799 L195 ECL2 hydrophobic
SAR247799 C206 5.43x43 TM5 Van der Waals
SAR247799 L272 6.51x51 TM6 hydrophobic
SAR247799 L276 6.55x55 TM6 Van der Waals
SAR247799 A293 7.35x34 TM7 hydrophobic
SAR247799 L297 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
Helix box plot — Download: PNG | SVG I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7

GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
ECL1
23x49 23.49x49 T108
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
TM4
4x56 4.56x56 L174
TM5
5x43 5.43x43 C206
TM6
6x51 6.51x51 L272
6x55 6.55x55 L276
TM7
7x34 7.35x34 A293
7x38 7.39x38 L297