PDB
8YN8
Resolution
2.8 Å
Released
Oct. 16, 2024
Receptor
H3
Class
A
Species
Homo sapiens
Ligand
proxyfan
Function
Agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
proxyfan D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
proxyfan Y115 3.33x33 TM3 Van der Waals
proxyfan Y115 3.33x33 TM3 hydrophobic
proxyfan C118 3.36x36 TM3 Van der Waals
proxyfan C118 3.36x36 TM3 hydrophobic
proxyfan Y167 4.57x57 TM4 hydrophobic
proxyfan Y167 4.57x57 TM4 Van der Waals
proxyfan S203 5.43x44 TM5 Van der Waals
proxyfan E206 5.46x461 TM5 polar (charge-assisted hydrogen bond)
proxyfan Y374 6.51x51 TM6 Van der Waals
proxyfan Y374 6.51x51 TM6 aromatic (face-to-edge)
proxyfan T375 6.52x52 TM6 Van der Waals
proxyfan F398 7.39x38 TM7 aromatic (face-to-face)
proxyfan F398 7.39x38 TM7 Van der Waals
proxyfan F398 7.39x38 TM7 polar (hydrogen bond with backbone)
proxyfan L401 7.42x41 TM7 hydrophobic
proxyfan L401 7.42x41 TM7 Van der Waals
proxyfan W402 7.43x42 TM7 polar (hydrogen bond)
proxyfan W402 7.43x42 TM7 aromatic (face-to-edge)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S S L R ICL1ECL1 G R W T F ECL1ICL2 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
Helix box plot — Download: PNG | SVG A N G L V T A V I L L A M L A A L V 1 L N L A I S D F L V G F A C I P L Y V P Y 2 L V I N F A S S T C L L Y D V V L W L K 3 A V R K M L L V W V L A F L L Y G P A 4 N F F T V S L F P T F F E L T S A T I L F 5 A V I V S I F G L C W A P Y T L L M I I 6 V P N V A S N A W L L W F S T E Y W Y 7

GPCRdb(A)
GPCRdb(A)
H3 receptor
TM3
3x32 3.32x32 D114
3x33 3.33x33 Y115
3x36 3.36x36 C118
TM4
4x57 4.57x57 Y167
TM5
5x44 5.43x44 S203
5x461 5.46x461 E206
TM6
6x51 6.51x51 Y374
6x52 6.52x52 T375
TM7
7x38 7.39x38 F398
7x41 7.42x41 L401
7x42 7.43x42 W402