PDB
8YNF
Resolution
3.7 Å
Released
Sept. 17, 2025
Receptor
ACKR1
Class
A
Species
Homo sapiens
Ligand
CXCL8 (IL-8)
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL8 (IL-8) E46 N-term polar (charge-assisted hydrogen bond)
CXCL8 (IL-8) A47 N-term Van der Waals
CXCL8 (IL-8) A49 N-term hydrophobic
CXCL8 (IL-8) A49 N-term Van der Waals
CXCL8 (IL-8) C51 N-term Van der Waals
CXCL8 (IL-8) S191 ECL2 Van der Waals
CXCL8 (IL-8) I198 ECL2 Van der Waals
CXCL8 (IL-8) Y199 ECL2 polar (hydrogen bond with backbone)
CXCL8 (IL-8) Y199 ECL2 Van der Waals
CXCL8 (IL-8) S200 ECL2 Van der Waals
CXCL8 (IL-8) R267 6.62x62 TM6 Van der Waals
CXCL8 (IL-8) S274 ECL3 Van der Waals
CXCL8 (IL-8) T275 7.24x23 TM7 polar (hydrogen bond with backbone)
CXCL8 (IL-8) T275 7.24x23 TM7 Van der Waals
CXCL8 (IL-8) C276 7.25x24 TM7 polar (hydrogen bond with backbone)
CXCL8 (IL-8) C276 7.25x24 TM7 Van der Waals
CXCL8 (IL-8) Q279 7.28x27 TM7 polar (hydrogen bond)
CXCL8 (IL-8) Q279 7.28x27 TM7 polar (hydrogen bond)
CXCL8 (IL-8) D283 7.32x31 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 L F R W Q L C P ICL1ECL1 P G L G S T R ECL1ICL2 G Q ICL2ECL2 G A S G G L C T L I Y S T E ECL2ICL3 K A L G M G ICL3ECL3 L L L L S ECL3N-term M G N C L H R A E L S P S T E N S S Q L D F E D V W N S S Y G V N D S F P D G D Y G A N L E A A A P C H S C N L L N-termC-term E G W S S H L D T L G S K S C-term D D S A L P F F I L T S V L G I L A S S T V L F M L F R P G W P V L A Q L A V G S A L F S I V V P V L A S S A L C S L G Y C V W Y G S A F A Q A L L L G C H A S L G H R L G A V P G L T L G L T V G I W G V A A L L T L P V T L A S L K A L Q A T H T V A C L A I F V L L P L G L F G A K G L K P G P W M N I L W A W F I F W W P H G V V L G L D F L V R S K T C L A Q Q A L D L L L N L A E A L A I L H C V A T P L L L A L F C H Q L L P P A T R T S L P L
Helix box plot — Download: PNG | SVG S S A L I G L V S T L I F F P L A S D D 1 A Q L A V G S A L F S I V V P V L A 2 C G L L L A Q A F A S G Y W V C Y G L S 3 T L G L T V G I W G V A A L L T L P V 4 F L G L P L L V F I A L C A V T H T A Q 5 M N I L W A W F I F W W P H G V V L G L 6 L P T A V C H L I A L A E A L N L L L 7

GPCRdb(A)
GPCRdb(A)
ACKR1
TM6
6x62 6.62x62 R267
TM7
7x23 7.24x23 T275
7x24 7.25x24 C276
7x27 7.28x27 Q279
7x31 7.32x31 D283