PDB
8YYX
Resolution
2.8 Å
Released
April 9, 2025
Receptor
oxoglutarate
Class
A
Species
Homo sapiens
Ligand
LTE4
Function
Allosteric agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
LTE4 L122 3.41x41 TM3 hydrophobic
LTE4 C141 ICL2 Van der Waals
LTE4 C141 ICL2 polar (hydrogen bond)
LTE4 R148 4.40x40 TM4 polar (charge-assisted hydrogen bond)
LTE4 C149 4.41x41 TM4 polar (hydrogen bond)
LTE4 C149 4.41x41 TM4 Van der Waals
LTE4 V152 4.44x44 TM4 hydrophobic
LTE4 V152 4.44x44 TM4 Van der Waals
LTE4 T205 5.45x46 TM5 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M R P W ICL1ECL1 G E N W I F ECL1ICL2 P M S C F S I H ICL2ECL2 T S T N R T N R S A C L D L T S S D E ECL2ICL3 G L Q T ICL3ECL3 R L L S I ECL3N-term M N E P L D Y L A N A S D F P D Y A A A F G N C T D E N I P N-termC-term C K V S G N L E Q A K K I S Y S N N P C-term L K M H Y L P V I Y G I I F L V G F P G N A V V I S T Y I F K K S S T I I M L N L A C T D L L Y L T S L P F L I H Y Y A S G D F M C K F I R F S F H F N L Y S S I L F L T C F S I F R Y C V I I H K T R C A V V A C A V V W I I S L V A V I P M T F L I L N T I K W Y N L I L T A T T F C L P L V I V T L C Y T T I I H T L T H D S C L K Q K A R R L T I L L L L A F Y V C F L P F H I L R V I R I E S S C S I E N Q I H E A Y I V S R P L A A L N T F G N L L L Y V V V S D N V C S F Q Q A T V R
Helix box plot — Download: PNG | SVG A N G P F G V L F I I G Y I V P L Y H M 1 L N L A C T D L L Y L T S L P F L I H Y 2 C T L F L I S S Y L N F H F S F R I F K 3 A V V A C A V V W I I S L V A V I P M 4 Y C L T V I V L P L C F T T A T L I L N Y 5 I L L L L A F Y V C F L P F H I L R V I 6 L L N G F T N L A A L P R S V I Y A E 7

GPCRdb(A)
GPCRdb(A)
oxoglutarate receptor
TM3
3x41 3.41x41 L122
TM4
4x40 4.40x40 R148
4x41 4.41x41 C149
4x44 4.44x44 V152
TM5
5x46 5.45x46 T205