PDB
8ZBJ
Resolution
2.9 Å
Released
April 30, 2025
Receptor
SST5
Class
A
Species
Homo sapiens
Ligand
SOMATOSTATIN
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN L96 2.60x60 TM2 hydrophobic
SOMATOSTATIN T185 ECL2 polar (hydrogen bond)
SOMATOSTATIN T185 ECL2 Van der Waals
SOMATOSTATIN N187 45.51x51 ECL2 Van der Waals
SOMATOSTATIN N187 45.51x51 ECL2 polar (hydrogen bond)
SOMATOSTATIN F201 5.38x39 TM5 hydrophobic
SOMATOSTATIN F264 6.51x51 TM6 aromatic (edge-to-face)
SOMATOSTATIN N268 6.55x55 TM6 Van der Waals
SOMATOSTATIN N271 6.58x58 TM6 Van der Waals
SOMATOSTATIN N271 6.58x58 TM6 polar (hydrogen bond)
SOMATOSTATIN L276 ECL3 Van der Waals
SOMATOSTATIN P277 ECL3 hydrophobic
SOMATOSTATIN P277 ECL3 Van der Waals
SOMATOSTATIN A283 7.32x31 TM7 hydrophobic
SOMATOSTATIN A283 7.32x31 TM7 Van der Waals
SOMATOSTATIN Y286 7.35x34 TM7 polar (hydrogen bond)
SOMATOSTATIN Y286 7.35x34 TM7 Van der Waals
SOMATOSTATIN F287 7.36x35 TM7 hydrophobic
SOMATOSTATIN F287 7.36x35 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
Helix box plot — Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x60 2.60x60 L96
ECL2
45x51 45.51x51 N187
TM5
5x39 5.38x39 F201
TM6
6x51 6.51x51 F264
6x55 6.55x55 N268
6x58 6.58x58 N271
TM7
7x31 7.32x31 A283
7x34 7.35x34 Y286
7x35 7.36x35 F287