Structure information

SST5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZCJ

SPECIES

Homo sapiens

RESOLUTION

3.090

PREFERRED CHAIN

G

REFERENCE

10.1038/S41401-024-01314-8

PUBLICATION DATE

July 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
004-DTR-LYS-TYR-PHA-HYP Y89 2.53x53 TM2 polar (hydrogen bond)
004-DTR-LYS-TYR-PHA-HYP L96 2.60x60 TM2 Van der Waals
004-DTR-LYS-TYR-PHA-HYP Q99 ECL1 polar (hydrogen bond)
004-DTR-LYS-TYR-PHA-HYP Q99 ECL1 Van der Waals
004-DTR-LYS-TYR-PHA-HYP M116 3.29x29 TM3 Van der Waals
004-DTR-LYS-TYR-PHA-HYP D119 3.32x32 TM3 Van der Waals
004-DTR-LYS-TYR-PHA-HYP G120 3.33x33 TM3 Van der Waals
004-DTR-LYS-TYR-PHA-HYP Q123 3.36x36 TM3 Van der Waals
004-DTR-LYS-TYR-PHA-HYP F124 3.37x37 TM3 hydrophobic
004-DTR-LYS-TYR-PHA-HYP F124 3.37x37 TM3 Van der Waals
004-DTR-LYS-TYR-PHA-HYP T185 ECL2 Van der Waals
004-DTR-LYS-TYR-PHA-HYP F201 5.38x39 TM5 hydrophobic
004-DTR-LYS-TYR-PHA-HYP F201 5.38x39 TM5 Van der Waals
004-DTR-LYS-TYR-PHA-HYP I202 5.39x40 TM5 Van der Waals
004-DTR-LYS-TYR-PHA-HYP I202 5.39x40 TM5 hydrophobic
004-DTR-LYS-TYR-PHA-HYP F264 6.51x51 TM6 Van der Waals
004-DTR-LYS-TYR-PHA-HYP F264 6.51x51 TM6 hydrophobic
004-DTR-LYS-TYR-PHA-HYP N268 6.55x55 TM6 polar (hydrogen bond)
004-DTR-LYS-TYR-PHA-HYP N268 6.55x55 TM6 polar (hydrogen bond)
004-DTR-LYS-TYR-PHA-HYP N271 6.58x58 TM6 polar (hydrogen bond)
004-DTR-LYS-TYR-PHA-HYP N271 6.58x58 TM6 Van der Waals
004-DTR-LYS-TYR-PHA-HYP L272 6.59x59 TM6 Van der Waals
004-DTR-LYS-TYR-PHA-HYP Q278 ECL3 Van der Waals
004-DTR-LYS-TYR-PHA-HYP S282 7.31x30 TM7 Van der Waals
004-DTR-LYS-TYR-PHA-HYP A283 7.32x31 TM7 hydrophobic
004-DTR-LYS-TYR-PHA-HYP A283 7.32x31 TM7 Van der Waals
004-DTR-LYS-TYR-PHA-HYP Y286 7.35x34 TM7 hydrophobic
004-DTR-LYS-TYR-PHA-HYP Y286 7.35x34 TM7 Van der Waals

Ligands

004-DTR-LYS-TYR-PHA-HYP

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Residue Diagrams

T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7
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ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x53 2.53x53 Y89
2x60 2.60x60 L96
TM3
3x29 3.29x29 M116
3x32 3.32x32 D119
3x33 3.33x33 G120
3x36 3.36x36 Q123
3x37 3.37x37 F124
TM5
5x39 5.38x39 F201
5x40 5.39x40 I202
TM6
6x51 6.51x51 F264
6x55 6.55x55 N268
6x58 6.58x58 N271
6x59 6.59x59 L272
TM7
7x30 7.31x30 S282
7x31 7.32x31 A283
7x34 7.35x34 Y286