PDB
8ZH8
Resolution
3.2 Å
Released
July 3, 2024
Receptor
QRFP
Class
A
Species
Homo sapiens
Ligand
QRFP26
Function
Agonist
Reference
10.1038/S41467-024-49030-5

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Ligand Amino Acid Generic Number Segment Interaction Type
QRFP26 A3 N-term polar (hydrogen bond with backbone)
QRFP26 A3 N-term Van der Waals
QRFP26 L4 N-term Van der Waals
QRFP26 N5 N-term polar (hydrogen bond with backbone)
QRFP26 N5 N-term Van der Waals
QRFP26 N5 N-term polar (hydrogen bond)
QRFP26 I6 N-term Van der Waals
QRFP26 H18 N-term Van der Waals
QRFP26 L20 N-term Van der Waals
QRFP26 L20 N-term hydrophobic
QRFP26 F25 N-term hydrophobic
QRFP26 F25 N-term Van der Waals
QRFP26 Y29 N-term polar (hydrogen bond)
QRFP26 Y29 N-term Van der Waals
QRFP26 L31 N-term Van der Waals
QRFP26 L31 N-term hydrophobic
QRFP26 R32 N-term Van der Waals
QRFP26 R32 N-term polar (hydrogen bond with backbone)
QRFP26 P33 N-term Van der Waals
QRFP26 P33 N-term polar (hydrogen bond with backbone)
QRFP26 L34 N-term polar (hydrogen bond with backbone)
QRFP26 L34 N-term Van der Waals
QRFP26 V35 N-term Van der Waals
QRFP26 V35 N-term hydrophobic
QRFP26 Y36 N-term Van der Waals
QRFP26 Y36 N-term polar (hydrogen bond with backbone)
QRFP26 T37 N-term Van der Waals
QRFP26 P38 N-term Van der Waals
QRFP26 P38 N-term hydrophobic
QRFP26 C98 2.57x56 TM2 Van der Waals
QRFP26 V101 2.60x59 TM2 hydrophobic
QRFP26 V101 2.60x59 TM2 Van der Waals
QRFP26 T102 2.61x60 TM2 Van der Waals
QRFP26 L104 2.63x62 TM2 Van der Waals
QRFP26 Q105 2.64x63 TM2 polar (hydrogen bond)
QRFP26 Q105 2.64x63 TM2 Van der Waals
QRFP26 Q105 2.64x63 TM2 polar (hydrogen bond)
QRFP26 S108 ECL1 Van der Waals
QRFP26 D109 ECL1 polar (hydrogen bond with backbone)
QRFP26 D109 ECL1 Van der Waals
QRFP26 N110 23.49x49 ECL1 Van der Waals
QRFP26 W111 23.50x50 ECL1 Van der Waals
QRFP26 W111 23.50x50 ECL1 aromatic (edge-to-face)
QRFP26 P122 3.29x29 TM3 hydrophobic
QRFP26 P122 3.29x29 TM3 Van der Waals
QRFP26 Q125 3.32x32 TM3 Van der Waals
QRFP26 Q125 3.32x32 TM3 polar (hydrogen bond)
QRFP26 V129 3.36x36 TM3 hydrophobic
QRFP26 Q184 ECL2 polar (hydrogen bond)
QRFP26 Q184 ECL2 Van der Waals
QRFP26 K189 ECL2 polar (charge-assisted hydrogen bond)
QRFP26 C200 ECL2 Van der Waals
QRFP26 C201 45.50x50 ECL2 Van der Waals
QRFP26 L202 45.51x51 ECL2 Van der Waals
QRFP26 L202 45.51x51 ECL2 hydrophobic
QRFP26 E203 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
QRFP26 Q211 5.35x36 TM5 Van der Waals
QRFP26 Y214 5.38x39 TM5 Van der Waals
QRFP26 Y214 5.38x39 TM5 hydrophobic
QRFP26 T215 5.39x40 TM5 Van der Waals
QRFP26 T215 5.39x40 TM5 polar (hydrogen bond with backbone)
QRFP26 T215 5.39x40 TM5 polar (hydrogen bond)
QRFP26 I218 5.42x43 TM5 Van der Waals
QRFP26 I218 5.42x43 TM5 hydrophobic
QRFP26 L222 5.46x461 TM5 Van der Waals
QRFP26 F289 6.51x51 TM6 hydrophobic
QRFP26 F289 6.51x51 TM6 Van der Waals
QRFP26 Q318 7.39x38 TM7 polar (hydrogen bond)
QRFP26 Q318 7.39x38 TM7 polar (hydrogen bond)
QRFP26 F322 7.43x42 TM7 Van der Waals
QRFP26 F322 7.43x42 TM7 hydrophobic

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ICL1 K A M R ICL1ECL1 D N W L G G A ECL1ICL2 P F K M K W Q Y ICL2ECL2 Q L E I K Y D F L Y E K E H I C C L E E W T ECL2ICL3 H G K E ICL3ECL3 N F E K E Y D ECL3N-term M Q A L N I T P E Q F S R L L R D H N L T R E Q F I A L Y R L R P L V Y T P E L N-termC-term N K T F S P A Q R H G N S G I T M M R K K A K F S L R E N P V E E T K G E A F S D G N I E V K L C E Q T E E K K K L K R H L A L F R S E L A E N S P L D S G H C-term P G R A K L A L V L T G V L I F A L A L F G N A L V F Y V V T R S T V T N I F I C S L A L S D L L I T F F C I P V T M L Q N I S F I C K M V P F V Q S T A V V T E I L T M T C I A V E R H Q G L V H T N R R A F T M L G V V W L V A V I V G S P M W H V Q S P V H Q K I Y T T F I L V I L F L L P L M V M L I L Y S K I G Y E L W I K K R V G D G S V L R T I M S K I A R K K K R A V I M M V T V V A L F A V C W A P F H V V H M M I E Y S D V T I K M I F A I V Q I I G F S N S I C N P I V Y A F M N E N V L S C I V F K K N A V C Y
Helix box plot — Download: PNG | SVG A N G F L A L A F I L V G T L V L A L K 1 C S L A L S D L L I T F F C I P V T M L Q 2 C T M T L I E T V V A T S Q V F P V M K 3 A F T M L G V V W L V A V I V G S P M W 4 Y L I L M V M L P L L F L I V L I F T T Y 5 V T V V A L F A V C W A P F H V V H M M 6 I P N C I S N S F G I I Q V I A F I M 7

GPCRdb(A)
GPCRdb(A)
QRFP receptor
TM2
2x56 2.57x56 C98
2x59 2.60x59 V101
2x60 2.61x60 T102
2x62 2.63x62 L104
2x63 2.64x63 Q105
ECL1
23x49 23.49x49 N110
23x50 23.50x50 W111
TM3
3x29 3.29x29 P122
3x32 3.32x32 Q125
3x36 3.36x36 V129
ECL2
45x50 45.50x50 C201
45x51 45.51x51 L202
45x52 45.52x52 E203
TM5
5x36 5.35x36 Q211
5x39 5.38x39 Y214
5x40 5.39x40 T215
5x43 5.42x43 I218
5x461 5.46x461 L222
TM6
6x51 6.51x51 F289
TM7
7x38 7.39x38 Q318
7x42 7.43x42 F322