PDB
8ZJG
Resolution
3.2 Å
Released
Jan. 22, 2025
Receptor
chemerin
Class
A
Species
Homo sapiens
Ligand
Chemerin
Function
Agonist
Reference
10.1038/S42003-024-07228-9

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin D20 N-term polar (hydrogen bond with backbone)
Chemerin D20 N-term polar (charge-assisted hydrogen bond)
Chemerin Y21 N-term Van der Waals
Chemerin Y21 N-term polar (hydrogen bond)
Chemerin L22 N-term Van der Waals
Chemerin L22 N-term polar (hydrogen bond with backbone)
Chemerin D23 N-term Van der Waals
Chemerin D23 N-term polar (hydrogen bond with backbone)
Chemerin S24 N-term Van der Waals
Chemerin I25 N-term Van der Waals
Chemerin I25 N-term polar (hydrogen bond with backbone)
Chemerin V26 N-term Van der Waals
Chemerin V27 N-term polar (hydrogen bond with backbone)
Chemerin V27 N-term Van der Waals
Chemerin L28 N-term hydrophobic
Chemerin F88 2.53x53 TM2 aromatic (edge-to-face)
Chemerin L92 2.57x57 TM2 Van der Waals
Chemerin L92 2.57x57 TM2 hydrophobic
Chemerin H95 2.60x60 TM2 Van der Waals
Chemerin H95 2.60x60 TM2 polar (hydrogen bond)
Chemerin Y103 ECL1 Van der Waals
Chemerin Y103 ECL1 hydrophobic
Chemerin N116 3.29x29 TM3 Van der Waals
Chemerin N116 3.29x29 TM3 polar (hydrogen bond)
Chemerin L119 3.32x32 TM3 Van der Waals
Chemerin L119 3.32x32 TM3 hydrophobic
Chemerin I120 3.33x33 TM3 hydrophobic
Chemerin I120 3.33x33 TM3 Van der Waals
Chemerin R178 ECL2 polar (charge-assisted hydrogen bond)
Chemerin L183 ECL2 hydrophobic
Chemerin H184 ECL2 Van der Waals
Chemerin H184 ECL2 polar (hydrogen bond)
Chemerin G185 ECL2 Van der Waals
Chemerin K186 ECL2 Van der Waals
Chemerin S188 ECL2 polar (hydrogen bond)
Chemerin S188 ECL2 Van der Waals
Chemerin F190 45.51x51 ECL2 Van der Waals
Chemerin F190 45.51x51 ECL2 hydrophobic
Chemerin N191 45.52x52 ECL2 polar (hydrogen bond)
Chemerin N191 45.52x52 ECL2 polar (hydrogen bond)
Chemerin N191 45.52x52 ECL2 polar (hydrogen bond with backbone)
Chemerin W203 ECL2 hydrophobic
Chemerin W203 ECL2 Van der Waals
Chemerin H217 5.35x36 TM5 Van der Waals
Chemerin R224 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Chemerin Y276 6.51x51 TM6 hydrophobic
Chemerin Y276 6.51x51 TM6 Van der Waals
Chemerin E283 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Chemerin H286 ECL3 polar (hydrogen bond with backbone)
Chemerin H286 ECL3 Van der Waals
Chemerin T287 ECL3 Van der Waals
Chemerin M289 ECL3 Van der Waals
Chemerin P290 ECL3 Van der Waals
Chemerin G291 ECL3 Van der Waals
Chemerin F294 7.31x30 TM7 hydrophobic
Chemerin F294 7.31x30 TM7 Van der Waals
Chemerin L298 7.35x34 TM7 Van der Waals
Chemerin L298 7.35x34 TM7 hydrophobic
Chemerin T302 7.39x38 TM7 Van der Waals
Chemerin I306 7.43x42 TM7 Van der Waals
Chemerin I306 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K K ICL1ECL1 Y H W V F ECL1ICL2 P V W S Q N H R ICL2ECL2 D T A N L H G K I S C F N N F S L S T P G S S S W P ECL2ICL3 L A K T ICL3ECL3 T A M ECL3N-term M R M E D E D Y N T S I S Y G D E Y P D Y L D S I V V L E D L S N-termC-term S R L V N A L S E D T G H S S Y P S H R S F T K M S S M N E R T S M N E R E T G M L C-term P L E A R V T R I F L V V V Y S I V C F L G I L G N G L V I I I A T F K T V N M V W F L N L A V A D F L F N V F L P I H I T Y A A M D G T A M C K I S N F L L I H N M F T S V F L L T I I S S D R C I S V L L S V R L A Y M A C M V I W V L A F F L S S P S L V F R T H S Q M D P V G Y S R H M V V T V T R F L C G F L V P V L I I T A C Y L T I V C K L Q R N R K K P F K I I V T I I I T F F L C W C P Y H T L N L L E L H H P G S V F S L G L P L A T A L A I A N S C M N P I L Y V F M G Q D K V A F K K F L F
Helix box plot — Download: PNG | SVG G N G L I G L F C V I S Y V V V L F I R 1 L N L A V A D F L F N V F L P I H I T Y 2 I T L L F V S T F M N H I L L F N S I K 3 A Y M A C M V I W V L A F F L S S P S 4 Y C A T I I L V P V L F G C L F R T V T V 5 V T I I I T F F L C W C P Y H T L N L L 6 I P N M C S N A I A L A T A L P L G L 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor
TM2
2x53 2.53x53 F88
2x57 2.57x57 L92
2x60 2.60x60 H95
TM3
3x29 3.29x29 N116
3x32 3.32x32 L119
3x33 3.33x33 I120
ECL2
45x51 45.51x51 F190
45x52 45.52x52 N191
TM5
5x36 5.35x36 H217
5x43 5.42x43 R224
TM6
6x51 6.51x51 Y276
6x58 6.58x58 E283
TM7
7x30 7.31x30 F294
7x34 7.35x34 L298
7x38 7.39x38 T302
7x42 7.43x42 I306