PDB
8ZSP
Resolution
3.1 Å
Released
July 24, 2024
Receptor
TA1
Class
A
Species
Homo sapiens
Ligand
(+)-LSD
Function
Agonist
Reference
10.1016/J.CELREP.2024.114505

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Ligand Amino Acid Generic Number Segment Interaction Type
(+)-LSD D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(+)-LSD I104 3.33x33 TM3 hydrophobic
(+)-LSD I104 3.33x33 TM3 Van der Waals
(+)-LSD S107 3.36x36 TM3 Van der Waals
(+)-LSD S108 3.37x37 TM3 polar (hydrogen bond)
(+)-LSD S183 45.51x51 ECL2 Van der Waals
(+)-LSD V184 45.52x52 ECL2 Van der Waals
(+)-LSD V184 45.52x52 ECL2 hydrophobic
(+)-LSD F186 ECL2 Van der Waals
(+)-LSD F186 ECL2 hydrophobic
(+)-LSD T194 5.42x43 TM5 Van der Waals
(+)-LSD S198 5.46x461 TM5 polar (hydrogen bond)
(+)-LSD W264 6.48x48 TM6 hydrophobic
(+)-LSD W264 6.48x48 TM6 Van der Waals
(+)-LSD F267 6.51x51 TM6 hydrophobic
(+)-LSD F267 6.51x51 TM6 Van der Waals
(+)-LSD F268 6.52x52 TM6 aromatic (edge-to-face)
(+)-LSD F268 6.52x52 TM6 Van der Waals
(+)-LSD I290 7.39x38 TM7 Van der Waals
(+)-LSD I290 7.39x38 TM7 hydrophobic
(+)-LSD Y294 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
Helix box plot — Download: PNG | SVG L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 S108
ECL2
45x51 45.51x51 S183
45x52 45.52x52 V184
TM5
5x43 5.42x43 T194
5x461 5.46x461 S198
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x38 7.39x38 I290
7x42 7.43x42 Y294