Structure information

TA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZSS

SPECIES

Homo sapiens

RESOLUTION

3.070

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 24, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
RO5256390 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
RO5256390 I104 3.33x33 TM3 Van der Waals
RO5256390 I104 3.33x33 TM3 hydrophobic
RO5256390 S107 3.36x36 TM3 polar (hydrogen bond)
RO5256390 V184 45.52x52 ECL2 Van der Waals
RO5256390 V184 45.52x52 ECL2 hydrophobic
RO5256390 F186 ECL2 Van der Waals
RO5256390 F186 ECL2 hydrophobic
RO5256390 T194 5.42x43 TM5 Van der Waals
RO5256390 W264 6.48x48 TM6 Van der Waals
RO5256390 W264 6.48x48 TM6 aromatic (face-to-edge)
RO5256390 F267 6.51x51 TM6 Van der Waals
RO5256390 F267 6.51x51 TM6 hydrophobic
RO5256390 F268 6.52x52 TM6 hydrophobic
RO5256390 F268 6.52x52 TM6 Van der Waals
RO5256390 I290 7.39x38 TM7 Van der Waals
RO5256390 I290 7.39x38 TM7 polar (hydrogen bond with backbone)
RO5256390 G293 7.42x41 TM7 Van der Waals
RO5256390 Y294 7.43x42 TM7 Van der Waals
RO5256390 Y294 7.43x42 TM7 hydrophobic

Ligands

RO5256390

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Residue Diagrams

L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7
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ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
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Residue Table


GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
ECL2
45x52 45.52x52 V184
TM5
5x43 5.42x43 T194
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x38 7.39x38 I290
7x41 7.42x41 G293
7x42 7.43x42 Y294